Design of a novel constant current pulsed iontophoretic stimulation device

C. A. Zakzewski; J. K.J. Li; D. W. Amory; E. Kalatzis-Manolakis

doi:10.1109/NEBC.1992.285925

Design of a novel constant current pulsed iontophoretic stimulation device

C. A. Zakzewski, J. K.J. Li, D. W. Amory, E. Kalatzis-Manolakis

School of Engineering, Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

An instrument for constant current iontophoretic transdermal drug delivery was designed, prototyped, and preliminarily tested in the New Zealand white rabbit. This flexible device has been designed to synthesize several constant current output waveshapes of selectable magnitude, frequency, and duty cycle. The output waveforms include the conventional DC and monophasic pulsed DC, as well as two novel iontophoretic waveforms-a trapezoidal and a symmetrical biphasic pulsed DC. Each waveform was used to deliver an angiotensin-converting enzyme inhibitor transdermally to a rabbit with induced hypertension to compare relative antihypertensive efficacy.

Original language	English (US)
Title of host publication	Proceedings of the 18th IEEE Annual Northeast Bioengineering Conference, NEBEC 1992
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	33-34
Number of pages	2
ISBN (Electronic)	0780309022
DOIs	https://doi.org/10.1109/NEBC.1992.285925
State	Published - 1992
Event	18th IEEE Annual Northeast Bioengineering Conference, NEBEC 1992 - Kingston, United States Duration: Mar 12 1992 → Mar 13 1992

Publication series

Name	Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
ISSN (Print)	1071-121X
ISSN (Electronic)	2160-7001

Conference

Conference	18th IEEE Annual Northeast Bioengineering Conference, NEBEC 1992
Country/Territory	United States
City	Kingston
Period	3/12/92 → 3/13/92

All Science Journal Classification (ASJC) codes

Bioengineering

Access to Document

10.1109/NEBC.1992.285925

Cite this

Zakzewski, C. A., Li, J. K. J., Amory, D. W., & Kalatzis-Manolakis, E. (1992). Design of a novel constant current pulsed iontophoretic stimulation device. In Proceedings of the 18th IEEE Annual Northeast Bioengineering Conference, NEBEC 1992 (pp. 33-34). Article 285925 (Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NEBC.1992.285925

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abstract = "An instrument for constant current iontophoretic transdermal drug delivery was designed, prototyped, and preliminarily tested in the New Zealand white rabbit. This flexible device has been designed to synthesize several constant current output waveshapes of selectable magnitude, frequency, and duty cycle. The output waveforms include the conventional DC and monophasic pulsed DC, as well as two novel iontophoretic waveforms-a trapezoidal and a symmetrical biphasic pulsed DC. Each waveform was used to deliver an angiotensin-converting enzyme inhibitor transdermally to a rabbit with induced hypertension to compare relative antihypertensive efficacy.",

author = "Zakzewski, {C. A.} and Li, {J. K.J.} and Amory, {D. W.} and E. Kalatzis-Manolakis",

note = "Publisher Copyright: {\textcopyright} 1992 IEEE.; 18th IEEE Annual Northeast Bioengineering Conference, NEBEC 1992 ; Conference date: 12-03-1992 Through 13-03-1992",

year = "1992",

doi = "10.1109/NEBC.1992.285925",

language = "English (US)",

series = "Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC",

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}

Zakzewski, CA, Li, JKJ, Amory, DW & Kalatzis-Manolakis, E 1992, Design of a novel constant current pulsed iontophoretic stimulation device. in Proceedings of the 18th IEEE Annual Northeast Bioengineering Conference, NEBEC 1992., 285925, Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC, Institute of Electrical and Electronics Engineers Inc., pp. 33-34, 18th IEEE Annual Northeast Bioengineering Conference, NEBEC 1992, Kingston, United States, 3/12/92. https://doi.org/10.1109/NEBC.1992.285925

Design of a novel constant current pulsed iontophoretic stimulation device. / Zakzewski, C. A.; Li, J. K.J.; Amory, D. W. et al.
Proceedings of the 18th IEEE Annual Northeast Bioengineering Conference, NEBEC 1992. Institute of Electrical and Electronics Engineers Inc., 1992. p. 33-34 285925 (Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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BT - Proceedings of the 18th IEEE Annual Northeast Bioengineering Conference, NEBEC 1992

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Zakzewski CA, Li JKJ, Amory DW, Kalatzis-Manolakis E. Design of a novel constant current pulsed iontophoretic stimulation device. In Proceedings of the 18th IEEE Annual Northeast Bioengineering Conference, NEBEC 1992. Institute of Electrical and Electronics Engineers Inc. 1992. p. 33-34. 285925. (Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC). doi: 10.1109/NEBC.1992.285925

Design of a novel constant current pulsed iontophoretic stimulation device

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