Design, synthesis, and characterization of hydroxyapatite particulates

Chun Wei Chen, Kullaiah Byrappa, Charles S. Oakes, Wojciech Sushanek, Richard E. Riman, Mamoru Senna, Kelly Brown, Kevor S. TenHuisen, Victor F. Janas

Research output: Contribution to journalConference articlepeer-review


New hydrothermal technology for the preparation of hydroxyapatite designer particulates has been developed. Phase diagrams were constructed for the pH dependent equilibrium between monetite and HA from 50 to 200°C. Thermodynamic calculations were completed using temperature dependent functions for the relevant solution phase and solid-liquid equilibria and solute species activity coefficients. Model accuracy was evaluated through experiment at 50, 100, and 200°C and pHs between 2.2 and 8.9. The thermodynamic calculations and experimental results are in good agreement. Stoichiometric, crystalline HA has also been prepared by heterogeneous reaction of Ca(OH)2 powder and aqueous (NH4)2HPO4 at room temperature using mechanochemical-hydrothermal methods. This method appears to have very good reproducibility in terms of crystallinity and chemical composition.

Original languageEnglish (US)
Pages (from-to)LL6.2.1-LL6.2.6
JournalMaterials Research Society Symposium - Proceedings
StatePublished - 2001
EventBiomaterials for Drug Delivery and Tissue Engineering - Boston, MA, United States
Duration: Nov 27 2000Nov 29 2000

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering


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