Design, synthesis, and characterization of hydroxyapatite particulates

Chun Wei Chen; Kullaiah Byrappa; Charles S. Oakes; Wojciech Sushanek; Richard E. Riman; Mamoru Senna; Kelly Brown; Kevor S. TenHuisen; Victor F. Janas

Design, synthesis, and characterization of hydroxyapatite particulates

Chun Wei Chen, Kullaiah Byrappa, Charles S. Oakes, Wojciech Sushanek, Richard E. Riman, Mamoru Senna, Kelly Brown, Kevor S. TenHuisen, Victor F. Janas

School of Engineering, Materials Science & Engineering

Research output: Contribution to journal › Conference article › peer-review

Abstract

New hydrothermal technology for the preparation of hydroxyapatite designer particulates has been developed. Phase diagrams were constructed for the pH dependent equilibrium between monetite and HA from 50 to 200°C. Thermodynamic calculations were completed using temperature dependent functions for the relevant solution phase and solid-liquid equilibria and solute species activity coefficients. Model accuracy was evaluated through experiment at 50, 100, and 200°C and pHs between 2.2 and 8.9. The thermodynamic calculations and experimental results are in good agreement. Stoichiometric, crystalline HA has also been prepared by heterogeneous reaction of Ca(OH)₂ powder and aqueous (NH₄)₂HPO₄ at room temperature using mechanochemical-hydrothermal methods. This method appears to have very good reproducibility in terms of crystallinity and chemical composition.

Original language	English (US)
Pages (from-to)	LL6.2.1-LL6.2.6
Journal	Materials Research Society Symposium - Proceedings
Volume	662
State	Published - 2001
Event	Biomaterials for Drug Delivery and Tissue Engineering - Boston, MA, United States Duration: Nov 27 2000 → Nov 29 2000

All Science Journal Classification (ASJC) codes

Materials Science(all)
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

Cite this

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title = "Design, synthesis, and characterization of hydroxyapatite particulates",

abstract = "New hydrothermal technology for the preparation of hydroxyapatite designer particulates has been developed. Phase diagrams were constructed for the pH dependent equilibrium between monetite and HA from 50 to 200°C. Thermodynamic calculations were completed using temperature dependent functions for the relevant solution phase and solid-liquid equilibria and solute species activity coefficients. Model accuracy was evaluated through experiment at 50, 100, and 200°C and pHs between 2.2 and 8.9. The thermodynamic calculations and experimental results are in good agreement. Stoichiometric, crystalline HA has also been prepared by heterogeneous reaction of Ca(OH)2 powder and aqueous (NH4)2HPO4 at room temperature using mechanochemical-hydrothermal methods. This method appears to have very good reproducibility in terms of crystallinity and chemical composition.",

author = "Chen, {Chun Wei} and Kullaiah Byrappa and Oakes, {Charles S.} and Wojciech Sushanek and Riman, {Richard E.} and Mamoru Senna and Kelly Brown and TenHuisen, {Kevor S.} and Janas, {Victor F.}",

year = "2001",

language = "English (US)",

volume = "662",

pages = "LL6.2.1--LL6.2.6",

journal = "Materials Research Society Symposium - Proceedings",

issn = "0272-9172",

publisher = "Materials Research Society",

note = "Biomaterials for Drug Delivery and Tissue Engineering ; Conference date: 27-11-2000 Through 29-11-2000",

}

TY - JOUR

T1 - Design, synthesis, and characterization of hydroxyapatite particulates

AU - Chen, Chun Wei

AU - Byrappa, Kullaiah

AU - Oakes, Charles S.

AU - Sushanek, Wojciech

AU - Riman, Richard E.

AU - Senna, Mamoru

AU - Brown, Kelly

AU - TenHuisen, Kevor S.

AU - Janas, Victor F.

PY - 2001

Y1 - 2001

N2 - New hydrothermal technology for the preparation of hydroxyapatite designer particulates has been developed. Phase diagrams were constructed for the pH dependent equilibrium between monetite and HA from 50 to 200°C. Thermodynamic calculations were completed using temperature dependent functions for the relevant solution phase and solid-liquid equilibria and solute species activity coefficients. Model accuracy was evaluated through experiment at 50, 100, and 200°C and pHs between 2.2 and 8.9. The thermodynamic calculations and experimental results are in good agreement. Stoichiometric, crystalline HA has also been prepared by heterogeneous reaction of Ca(OH)2 powder and aqueous (NH4)2HPO4 at room temperature using mechanochemical-hydrothermal methods. This method appears to have very good reproducibility in terms of crystallinity and chemical composition.

AB - New hydrothermal technology for the preparation of hydroxyapatite designer particulates has been developed. Phase diagrams were constructed for the pH dependent equilibrium between monetite and HA from 50 to 200°C. Thermodynamic calculations were completed using temperature dependent functions for the relevant solution phase and solid-liquid equilibria and solute species activity coefficients. Model accuracy was evaluated through experiment at 50, 100, and 200°C and pHs between 2.2 and 8.9. The thermodynamic calculations and experimental results are in good agreement. Stoichiometric, crystalline HA has also been prepared by heterogeneous reaction of Ca(OH)2 powder and aqueous (NH4)2HPO4 at room temperature using mechanochemical-hydrothermal methods. This method appears to have very good reproducibility in terms of crystallinity and chemical composition.

UR - http://www.scopus.com/inward/record.url?scp=0035559819&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035559819&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:0035559819

SN - 0272-9172

VL - 662

SP - LL6.2.1-LL6.2.6

JO - Materials Research Society Symposium - Proceedings

JF - Materials Research Society Symposium - Proceedings

T2 - Biomaterials for Drug Delivery and Tissue Engineering

Y2 - 27 November 2000 through 29 November 2000

ER -

Design, synthesis, and characterization of hydroxyapatite particulates

Abstract

All Science Journal Classification (ASJC) codes

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