Designing tunable bio-nanostructured materials via self-assembly of amphiphilic lipids and functionalized nanotubes

Meenakshi Dutt, Olga Kuksenok, Anna C. Balazs

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

Via the Dissipative Particle Dynamics (DPD) approach, we study the self-assembly of hybrid structures comprising lipids and end-functionalized nanotubes. Individual lipids are composed of a hydrophilic head group and two hydrophobic tails. Each bare nanotube encompasses an ABA architecture, with a hydrophobic shaft (B) and two hydrophilic ends (A). To allow for regulated transport through the nanotube, we also introduce hydrophilic hairs at one end of the tube. The amphiphilic lipids are composed of a hydrophilic head group (A) and two hydrophobic tails (B). We select the dimensions of the nanotube architecture to minimize its hydrophobic mismatch with the lipid bilayer. We find the amphiphilic lipids and functionalized nanotubes to self-assemble into a stable hybrid vesicle or a bicelle in the presence of a hydrophilic solvent. We demonstrate that the morphology of the self-assembled functionalized nanotube-lipid hybrid structures is controlled by the rigidity of the lipid molecules and concentration of the nanotubes.

Original languageEnglish (US)
Title of host publicationMolecules to Materials - Multiscale Interfacial Phenomena in Biological and Bio-Inspired Materials
Pages1-6
Number of pages6
DOIs
StatePublished - Dec 1 2012
Event2012 MRS Spring Meeting - San Francisco, CA, United States
Duration: Apr 9 2012Apr 13 2012

Publication series

NameMaterials Research Society Symposium Proceedings
Volume1464
ISSN (Print)0272-9172

Other

Other2012 MRS Spring Meeting
CountryUnited States
CitySan Francisco, CA
Period4/9/124/13/12

Fingerprint

Nanostructured materials
Self assembly
Nanotubes
Lipids
lipids
self assembly
nanotubes
hybrid structures
Lipid bilayers
hair
rigidity
Rigidity
tubes
Molecules
molecules

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Dutt, M., Kuksenok, O., & Balazs, A. C. (2012). Designing tunable bio-nanostructured materials via self-assembly of amphiphilic lipids and functionalized nanotubes. In Molecules to Materials - Multiscale Interfacial Phenomena in Biological and Bio-Inspired Materials (pp. 1-6). (Materials Research Society Symposium Proceedings; Vol. 1464). https://doi.org/10.1557/opl.2012.1471
Dutt, Meenakshi ; Kuksenok, Olga ; Balazs, Anna C. / Designing tunable bio-nanostructured materials via self-assembly of amphiphilic lipids and functionalized nanotubes. Molecules to Materials - Multiscale Interfacial Phenomena in Biological and Bio-Inspired Materials. 2012. pp. 1-6 (Materials Research Society Symposium Proceedings).
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Dutt, M, Kuksenok, O & Balazs, AC 2012, Designing tunable bio-nanostructured materials via self-assembly of amphiphilic lipids and functionalized nanotubes. in Molecules to Materials - Multiscale Interfacial Phenomena in Biological and Bio-Inspired Materials. Materials Research Society Symposium Proceedings, vol. 1464, pp. 1-6, 2012 MRS Spring Meeting, San Francisco, CA, United States, 4/9/12. https://doi.org/10.1557/opl.2012.1471

Designing tunable bio-nanostructured materials via self-assembly of amphiphilic lipids and functionalized nanotubes. / Dutt, Meenakshi; Kuksenok, Olga; Balazs, Anna C.

Molecules to Materials - Multiscale Interfacial Phenomena in Biological and Bio-Inspired Materials. 2012. p. 1-6 (Materials Research Society Symposium Proceedings; Vol. 1464).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Dutt M, Kuksenok O, Balazs AC. Designing tunable bio-nanostructured materials via self-assembly of amphiphilic lipids and functionalized nanotubes. In Molecules to Materials - Multiscale Interfacial Phenomena in Biological and Bio-Inspired Materials. 2012. p. 1-6. (Materials Research Society Symposium Proceedings). https://doi.org/10.1557/opl.2012.1471