Detection of Candida auris Antifungal Drug Resistance Markers Directly from Clinical Skin Swabs

Milena Kordalewska, Annie Lee, Yanan Zhao, David S. Perlin

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Accurate and rapid assessment of Candida auris antifungal drug resistance is crucial for effective infection prevention and control actions, as well as for patient management. Here, performance of a molecular diagnostic platform, enabling rapid identification of FKS1 and ERG11 mutations conferring echinocandin and azole resistance, respectively, was evaluated on a panel of clinical skin swabs. Gene sequencing and antifungal susceptibility testing were used as the gold standard. All swabs were correctly categorized as harboring wild-type or mutant C. auris.

Original languageEnglish (US)
Article numbere01754-19
JournalAntimicrobial agents and chemotherapy
Volume63
Issue number12
DOIs
StatePublished - 2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Keywords

  • Antifungal resistance
  • Antifungal susceptibility testing
  • Azoles
  • Candida
  • Candida auris
  • Diagnostics
  • Drug resistance mechanisms
  • Echinocandins

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