Detection of H-2Db antigen on osmotic shock-treated friend leukemia virus particles

Suzie Chen, Frank Lilly

Research output: Contribution to journalArticle

11 Scopus citations


Antisera specific for either H-2Kb, H-2Db, H-2Kk or H-2Dk antigenic determinants were examined for their capacity to neutralize Friend virus (FV) collected from the serum of infected H-2b/H-2k heterozygous mice. Neutralizing activity was detected (1) only with anti-H-2Db antisera, (2) only when the surface of virus particles had been mildly deranged by osmotic shock treatment and (3) only in the assay for the defective spleen focus-forming virus component of FV.

Original languageEnglish (US)
Pages (from-to)25-31
Number of pages7
Issue number1
StatePublished - Dec 1 1979
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology
  • Genetics

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