Detection of the mcr-1 colistin resistance gene in carbapenem-resistant Enterobacteriaceae from different hospitals in China

Hua Yu, Fen Qu, Bin Shan, Bin Huang, Wei Jia, Cha Chen, Aiqing Li, Minhui Miao, Xin Zhang, Chunmei Bao, Yunmin Xu, Kalyan D. Chavda, Yi Wei Tang, Barry N. Kreiswirth, Hong Du, Liang Chen

Research output: Contribution to journalArticlepeer-review

74 Scopus citations

Abstract

The spread of the plasmid-mediated colistin resistance gene, mcr-1, into carbapenem-resistant Enterobacteriaceae (CRE) clinical isolates poses a significant threat to global health. Here we report the identification of three mcr-1-harboring carbapenem-resistant Escherichia coli strains, collected from three patients in two provinces in China. Our results show that mcr-1-harboring CRE strains have started to spread in different hospitals in China. In addition, this report presents the first description of chromosomal integration of mcr-1 into a carbapenem-resistant E. coli strain.

Original languageEnglish (US)
Pages (from-to)5033-5035
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume60
Issue number8
DOIs
StatePublished - Aug 2016

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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