Detection of the reelin breakpoint in reeler mice

Gabriella D'Arcangelo, Graham G. Miao, Tom Curran

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

Disruption of the reelin gene by partial deletion causes the neurological phenotype known as reeler. Here we report the cloning and sequencing of the reelin breakpoint region from the Jackson reeler strain (rl). Based on this sequence, we developed a polymerase chain reaction screen that allows the identification of mutant mice prior to the appearance of the phenotype. The assay also permits discrimination of heterozygous from wild-type mice. These findings provide a strategy for the characterization of the early anatomical and physiological consequences of the reeler mutation.

Original languageEnglish (US)
Pages (from-to)234-236
Number of pages3
JournalMolecular Brain Research
Volume39
Issue number1-2
DOIs
StatePublished - Jul 1996

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Keywords

  • Brain
  • Central nervous system
  • Extracellular matrix
  • Gene
  • Polymerase chain reaction
  • Reeler mouse

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