2′‐Deoxy‐D‐ribonucleoside analogs of biologically active 2‐β‐D‐ribofuranosylthiazole‐4‐carboxamide were synthesized and the structure of the β anomer was determined by X‐ray crystallography and ′1H nmr. 2′‐Methylene protons of α‐ and β‐deoxyribonucleosides were observed to exhibit characteristic patterns in the 1H nmr which was used to distinguish between the two anomers. The method could be used to determine the anomeric configuration of both N‐ and C‐2′‐deoxyribonucleosides.
All Science Journal Classification (ASJC) codes
- Organic Chemistry