@inproceedings{bd89496220a24c4192f501f18445810d,
title = "Development of a high-throughput micro-neurocircuitry platform for drug screening studies",
abstract = "Models for studying the onset and development of neuropsychiatric disorders have generally been limited to single or co-cultured mixed cell populations in vitro or animal models. While these approaches shed light on important disease mechanisms, they either do not capture the complex circuitry of the brain or limit translation of findings due to species differences. Here, we have used induced neurons (iNs) derived from patient-specific induced pluripotent stem cells within an arrayed microdevice which compartmentalizes iNs into two chambers. We demonstrate that we can form a functional circuit, which can be perturbed by various small molecules.",
keywords = "Calcium imaging, Compartmentalization, DREADDs, High-throughput, Induced neurons, Microfluidics, Stem cells",
author = "Fantuzzo, {Joseph A.} and Mirabella, {Vincent R.} and Hart, {Ronald P.} and Pang, {Zhiping P.} and Zahn, {Jeffrey D.}",
year = "2018",
month = jan,
day = "1",
language = "English (US)",
series = "22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018",
publisher = "Chemical and Biological Microsystems Society",
pages = "287--290",
booktitle = "22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018",
note = "22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 ; Conference date: 11-11-2018 Through 15-11-2018",
}