Development of a platform for microscale monitoring of cell function and differentiation

O. T. Guenat, S. Generelli, P. A. Clerc, N. F. De Rooij, M. Koudelka-Hep, F. Berthiaume, M. L. Yarmush

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

We present the technological development of a platform aimed for the monitoring of cell function and differentiation. The platform is equipped with an array of 16 silicon nitride micropipettes (diameter = 3 μm), located at the bottom of a 350 μm deep microchannel, and with two microfluidic drug delivery systems placed on both sides of the microchannel. The micropipettes house ion selective microelectrodes and the microfluidics serve to deliver growth and differentiation factors to cells to be cultured at the bottom of the channels. We are currently developing such a system using NH4+-selective microelectrodes to monitor the differentiation of stem cells into hepatocytes.

Original languageEnglish (US)
Title of host publication2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
Pages343-344
Number of pages2
DOIs
StatePublished - 2005
Externally publishedYes
Event2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology - Oahu, HI, United States
Duration: May 12 2005May 15 2005

Publication series

Name2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
Volume2005

Other

Other2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
Country/TerritoryUnited States
CityOahu, HI
Period5/12/055/15/05

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Keywords

  • Cell differentiation
  • Ion-selective electrode
  • Local drug delivery
  • Micropipette

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