Abstract
Several factors enhancing berberine production in Thalictrum rugosum cultures were found. Some of them enhanced both cell growth and product formation, but others resulted in a decoupling of growth and product formation with significant enhancement in the specific product level. Since berberine production usually follows growth-associated product formation kinetics, we looked to develop a process strategy using enhancing factors in an optimal fashion. Combination of positive effectors was discovered to have a synergistic effect and increased product formation considerably.
Original language | English (US) |
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Pages (from-to) | 201-207 |
Number of pages | 7 |
Journal | Journal of Biotechnology |
Volume | 21 |
Issue number | 3 |
DOIs | |
State | Published - Dec 1991 |
All Science Journal Classification (ASJC) codes
- Biotechnology
- Bioengineering
- Applied Microbiology and Biotechnology
Keywords
- Berberine
- Cell culture
- Process strategy
- Secondary metabolite
- Thalictrum rugosum