Development of process strategies for berberine production in plant cell suspension cultures

Dong Il Kim, Henrik Pedersen, Chee Kok Chin

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Several factors enhancing berberine production in Thalictrum rugosum cultures were found. Some of them enhanced both cell growth and product formation, but others resulted in a decoupling of growth and product formation with significant enhancement in the specific product level. Since berberine production usually follows growth-associated product formation kinetics, we looked to develop a process strategy using enhancing factors in an optimal fashion. Combination of positive effectors was discovered to have a synergistic effect and increased product formation considerably.

Original languageEnglish (US)
Pages (from-to)201-207
Number of pages7
JournalJournal of Biotechnology
Volume21
Issue number3
DOIs
StatePublished - Dec 1991

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

Keywords

  • Berberine
  • Cell culture
  • Process strategy
  • Secondary metabolite
  • Thalictrum rugosum

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