Developmental and abnormal cell death in C. Elegans

Monica Driscoll, Martin Chalfie

Research output: Contribution to journalReview articlepeer-review

66 Scopus citations


Genetic analysis in Caenorhabditis elegans has identified several genes that function in normal developmental death as well as genes that can mutate to cause inappropriate cell death. The processes whereby some of these abnormal deaths occur depend on genes that participate in normal programmed cell death; others occur by an independent mechanism whereby mutation of members of a gene family leads to cell lysis. Molecular characterization of these 'death' genes in C, elegans is beginning to provide insight into the normal and aberrant mechanisms of cell death.

Original languageEnglish (US)
Pages (from-to)15-19
Number of pages5
JournalTrends in Neurosciences
Issue number1
StatePublished - Jan 1992

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)


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