Developmental Effects of Endocrine-Disrupting Chemicals in the Ovary and on Female Fertility

Mehmet Uzumcu, Aparna Mahakali Zama

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Environmental conditions during critical developmental periods have a long-lasting influence over the physiology and behavior of an individual. Also known as the developmental origins of health and disease hypothesis, this concept applies to the effects of environmental endocrine-disrupting chemicals (EDCs) on the female reproductive system. In this chapter, we review the roles of EDCs (phthalates, organochlorine pesticides, dioxins, and diethylstilbestrol) on the emergence of female reproductive system pathologies with a focus on the ovary. Ovarian development and folliculogenesis, highlighting processes susceptible to the actions of EDCs, including epigenetic processes, are also reviewed. Animal studies using environmentally relevant doses support the hypothesis that EDCs can have long-lasting effects in the ovary, leading to female reproductive pathologies. From a basic research perspective, using advanced techniques for comprehensive genome-wide expression and epigenetic analyses, coupled with animal studies will help us to better understand the effects of EDCs in the ovary.

Original languageEnglish (US)
Title of host publicationThe Epigenome and Developmental Origins of Health and Disease
PublisherElsevier Inc.
Pages143-170
Number of pages28
ISBN (Electronic)9780128013830
ISBN (Print)9780128016725
DOIs
StatePublished - Oct 26 2015

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Keywords

  • ESR1
  • ESR2
  • Endocrine disruptors
  • Epigenetics
  • Female reproduction
  • Folliculogenesis
  • Gonadal development
  • Ovary

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