Developmental expression of the zinc finger transcription factor DRRF (dopamine receptor regulating factor)

Ursula M. D'Souza, Claas Hinrich Lammers, Cheol Kyu Hwang, Shunsuke Yajima, M Maral Mouradian

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Dopamine receptor regulating factor (DRRF) is a novel transcription factor with unique anatomical distribution and functional properties, suggesting its importance in regulating dopaminergic neurotransmission. To gain insight into the in vivo function of this factor during embryogenesis, we studied its distribution at embryonic days E8-E16 in the mouse using in situ hybridization. DRRF mRNA is expressed uniquely during development at all time points tested with high levels observed at E12, E14 and E16 in various tissues. DRRF expression is also found in particular brain regions, such as the neopallial cortex, olfactory lobe and corpus striatum. This pattern of DRRF distribution during embryogenesis overlaps with that found in the adult brain, and with the expression profile of dopamine receptors both in the adult and during development. Crown Copyright.

Original languageEnglish (US)
Pages (from-to)197-201
Number of pages5
JournalMechanisms of Development
Volume110
Issue number1-2
DOIs
StatePublished - Jan 2002

All Science Journal Classification (ASJC) codes

  • Embryology
  • Developmental Biology

Keywords

  • Dopamine receptor regulating factor
  • Dopaminergic neurotransmission
  • Embryogenesis

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