Diabetic retinopathy: More than meets the eye

Thomas W. Gardner, David A. Antonetti, Alistair J. Barber, Kathryn F. LaNoue, Steven W. Levison

Research output: Contribution to journalReview articlepeer-review

446 Scopus citations

Abstract

Retinal microvascular dysfunction in diabetes is a major component of diabetic retinopathy. This review highlights recent observations regarding the cellular anatomy that contributes to the blood-retinal barrier and its breakdown, the alterations of macroglial, neuronal, and microglial cells in diabetes, and how these changes lead to loss of vision. In addition, the effects of systemic pathophysiologic influences, including metabolic control, blood pressure, and fluid volume on the formation of diabetic macular edema are discussed. Finally, an overview of inflammatory mechanisms and responses in the retina in diabetes is provided. Together, these new observations provide a broader clinical and research perspective on diabetic retinal vascular dysfunction than previously considered, and provide new avenues for improved treatments to prevent loss of vision.

Original languageEnglish (US)
Pages (from-to)S253-S262
JournalSurvey of ophthalmology
Volume47
Issue numberSUPPL. 2
DOIs
StatePublished - Dec 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Keywords

  • Chronic inflammation
  • Diabetic retinopathy
  • Microglia
  • Retinal gliosis
  • Tight junction proteins

Fingerprint

Dive into the research topics of 'Diabetic retinopathy: More than meets the eye'. Together they form a unique fingerprint.

Cite this