Diagnosing Lyme disease

often simple, often difficult.

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Lyme disease has as its hallmark erythema migrans. However, it is only present in about one half of the patients who contract this disease. In its absence, the diagnosis of Lyme disease may be difficult. It depends upon a compatible history of exposure and clinical signs and symptoms together with positive results of serologic testing. Unfortunately, seronegativity for antibody to the pathogen may occur both during the first six weeks of infection and be chronic due to the reactive antibody being bound in immune complexes. The selective use of new diagnostic tests may be required to confirm the diagnosis. These tests include assays for antibody or antigen analysis of immune complex components, as well as polymerase chain reactions.

Original languageEnglish (US)
JournalCutis; cutaneous medicine for the practitioner
Volume47
Issue number4
StatePublished - Jan 1 1991

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Lyme Disease
Antigen-Antibody Complex
Antibodies
Erythema
Routine Diagnostic Tests
Signs and Symptoms
Antigens
Polymerase Chain Reaction
Infection

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

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title = "Diagnosing Lyme disease: often simple, often difficult.",
abstract = "Lyme disease has as its hallmark erythema migrans. However, it is only present in about one half of the patients who contract this disease. In its absence, the diagnosis of Lyme disease may be difficult. It depends upon a compatible history of exposure and clinical signs and symptoms together with positive results of serologic testing. Unfortunately, seronegativity for antibody to the pathogen may occur both during the first six weeks of infection and be chronic due to the reactive antibody being bound in immune complexes. The selective use of new diagnostic tests may be required to confirm the diagnosis. These tests include assays for antibody or antigen analysis of immune complex components, as well as polymerase chain reactions.",
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Diagnosing Lyme disease : often simple, often difficult. / Schutzer, Steven; Schwartz, Robert.

In: Cutis; cutaneous medicine for the practitioner, Vol. 47, No. 4, 01.01.1991.

Research output: Contribution to journalReview article

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T1 - Diagnosing Lyme disease

T2 - often simple, often difficult.

AU - Schutzer, Steven

AU - Schwartz, Robert

PY - 1991/1/1

Y1 - 1991/1/1

N2 - Lyme disease has as its hallmark erythema migrans. However, it is only present in about one half of the patients who contract this disease. In its absence, the diagnosis of Lyme disease may be difficult. It depends upon a compatible history of exposure and clinical signs and symptoms together with positive results of serologic testing. Unfortunately, seronegativity for antibody to the pathogen may occur both during the first six weeks of infection and be chronic due to the reactive antibody being bound in immune complexes. The selective use of new diagnostic tests may be required to confirm the diagnosis. These tests include assays for antibody or antigen analysis of immune complex components, as well as polymerase chain reactions.

AB - Lyme disease has as its hallmark erythema migrans. However, it is only present in about one half of the patients who contract this disease. In its absence, the diagnosis of Lyme disease may be difficult. It depends upon a compatible history of exposure and clinical signs and symptoms together with positive results of serologic testing. Unfortunately, seronegativity for antibody to the pathogen may occur both during the first six weeks of infection and be chronic due to the reactive antibody being bound in immune complexes. The selective use of new diagnostic tests may be required to confirm the diagnosis. These tests include assays for antibody or antigen analysis of immune complex components, as well as polymerase chain reactions.

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M3 - Review article

VL - 47

JO - Cutis

JF - Cutis

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