Diagnosis of systemic sarcoidosis prompted by orofacial manifestations: A review of the literature

Mahnaz Fatahzadeh, Joseph Rinaggio

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Background. Sarcoidosis is a multifactorial systemic inflammatory disorder of unknown origin characterized by many potential signs and symptoms, as well as by the presence of noncaseating granulomas in the organs involved. Sarcoidosis also may manifest in the oral and maxillofacial region. Case Description. The authors describe a patient with xerostomia, dysgeusia, oral burning, xerophthalmia and bilateral parotid enlargement. She was diagnosed as having systemic Sarcoidosis on the basis of the histologic findings of a biopsy of the labial minor salivary gland, as well as subsequent diagnostic evaluations. Conclusion and Clinical Implications. Enlargement of major salivary glands may be the first sign of sarcoidosis in a patient with few other symptoms or clinical findings suggestive of the disease. This case emphasizes the importance of including sarcoidosis in the differential diagnosis of bilateral parotid swelling associated with xerostomia. It also highlights the dentist's potential role in the diagnosis and dental treatment of patients with systemic sarcoidosis.

Original languageEnglish (US)
Pages (from-to)54-60
Number of pages7
JournalJournal of the American Dental Association
Issue number1
StatePublished - Jan 2006

All Science Journal Classification (ASJC) codes

  • General Dentistry


  • Granulomatous inflammation
  • Parotid enlargement
  • Sarcoidosis
  • Xerostomia


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