Dietary administration of an extract from rosemary leaves enhances the liver microsomal metabolism of endogenous estrogens and decreases their uterotropic action in CD-1 mice

Bao Ting Zhu, Daniel P. Loder, May Xiaoxin Cai, Chi Tang Ho, Mou Tuan Huang, Allan H. Conney

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

We evaluated the effects of a methanol extract from the leaves of the plant Rosmarinus officinalis L. (rosemary) on the metabolism and action of estradiol and estrone. Treatment of female CD-1 mice with 2% rosemary in AIN-76A diet for 3 weeks increased the liver microsomal 2-hydroxylation of estradiol and estrone by ~ 150%, increased their 6-hydroxylation by ~ 30% and inhibited the 16α-hydroxylation of estradiol by ~ 50%. Treatment of female CD-1 mice with 2% rosemary diet for 3 weeks also stimulated the liver microsomal glucuronidation of estradiol and estrone by 54-67% and 37-56%, respectively. In additional studies, feeding 2% rosemary diet to ovariectomized CD-1 mice for 3 weeks inhibited the uterotropic action of estradiol and estrone by 35-50% compared with animals fed a control diet. The results of this study showed that feeding female mice a 2% rosemary diet increased the liver microsomal oxidation and glucuronidation of estradiol and estrone and inhibited their uterotropic action.

Original languageEnglish (US)
Pages (from-to)1821-1827
Number of pages7
JournalCarcinogenesis
Volume19
Issue number10
DOIs
StatePublished - Oct 1998

All Science Journal Classification (ASJC) codes

  • Cancer Research

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