Differential contributions of dorsal vs. ventral hippocampus to auditory trace fear conditioning

Taejib Yoon, Tim Otto

Research output: Contribution to journalArticle

82 Scopus citations

Abstract

The effect of excitotoxic lesions of dorsal vs. ventral hippocampus on the acquisition and expression of auditory trace fear conditioning was examined in two studies. In Experiment 1, animals received excitotoxic lesions of either the dorsal or ventral hippocampus or sham surgeries one week prior to conditioning, and were tested 24 h later. In Experiment 2, animals received excitotoxic lesions of either the dorsal or ventral hippocampus or sham surgeries 24 h after training, and were tested one week after surgery. Both pre- and post-training lesions of ventral hippocampus impaired the acquisition and expression, respectively, of auditory trace fear conditioning. Pre-training lesions of dorsal hippocampus had no effect on the acquisition of trace fear conditioning, while post-training lesions of dorsal hippocampus dramatically impaired expression during subsequent testing. Although in some cases animals with lesions of ventral hippocampus exhibited locomotor hyperactivity, it is unlikely that the pattern of observed deficits can be attributed to this effect. Collectively these data suggest that the dorsal and ventral hippocampus may contribute differentially to the mnemonic processes underlying fear trace conditioning.

Original languageEnglish (US)
Pages (from-to)464-475
Number of pages12
JournalNeurobiology of Learning and Memory
Volume87
Issue number4
DOIs
StatePublished - May 1 2007

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Keywords

  • Dorsal hippocampus
  • Fear conditioning
  • Learning
  • Memory
  • Pavlovian conditioning
  • Rat
  • Trace conditioning
  • Ventral hippocampus

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