Differential development of central dopaminergic and serotonergic systems in BALB/c and C57BL/6J mice

Carrie L. Yochum, Christopher M. Medvecky, Michelle A. Cheh, Prianka Bhattacharya, George Wagner

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Although the etiology of autism is unclear, disruptions of the dopaminergic and serotonergic systems have been associated with the disorder. Based on behavioral differences observed in the BALB/c strain of mice in comparison to other strains, notably, C57BL/6J mice, it has been suggested that the BALB/c strain may serve as an animal model of autism. However, to date, most work investigating neural and behavioral abnormalities in this strain has been performed in adult animals. Therefore, the present study was conducted to examine the development of the central dopaminergic and serotonergic systems of BALB/c mice as compared to C57BL/6J mice. Levels of dopamine, serotonin, and their metabolites in several different brain regions and at three ages during development were measured. Alterations in both monoaminergic systems associated with age and strain were detected across brain regions indicating that there are neurochemical differences between these strains early in life. However, despite these differences in the development of brain monoaminergic systems, it remains difficult to declare this strain as a valid model of autism.

Original languageEnglish (US)
Pages (from-to)97-104
Number of pages8
JournalBrain research
Volume1349
DOIs
StatePublished - Aug 19 2010

Fingerprint

Autistic Disorder
Inbred C57BL Mouse
Brain
Dopamine
Serotonin
Animal Models

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Yochum, Carrie L. ; Medvecky, Christopher M. ; Cheh, Michelle A. ; Bhattacharya, Prianka ; Wagner, George. / Differential development of central dopaminergic and serotonergic systems in BALB/c and C57BL/6J mice. In: Brain research. 2010 ; Vol. 1349. pp. 97-104.
@article{2f787068f6b545d9a44be099e84c7bb2,
title = "Differential development of central dopaminergic and serotonergic systems in BALB/c and C57BL/6J mice",
abstract = "Although the etiology of autism is unclear, disruptions of the dopaminergic and serotonergic systems have been associated with the disorder. Based on behavioral differences observed in the BALB/c strain of mice in comparison to other strains, notably, C57BL/6J mice, it has been suggested that the BALB/c strain may serve as an animal model of autism. However, to date, most work investigating neural and behavioral abnormalities in this strain has been performed in adult animals. Therefore, the present study was conducted to examine the development of the central dopaminergic and serotonergic systems of BALB/c mice as compared to C57BL/6J mice. Levels of dopamine, serotonin, and their metabolites in several different brain regions and at three ages during development were measured. Alterations in both monoaminergic systems associated with age and strain were detected across brain regions indicating that there are neurochemical differences between these strains early in life. However, despite these differences in the development of brain monoaminergic systems, it remains difficult to declare this strain as a valid model of autism.",
author = "Yochum, {Carrie L.} and Medvecky, {Christopher M.} and Cheh, {Michelle A.} and Prianka Bhattacharya and George Wagner",
year = "2010",
month = "8",
day = "19",
doi = "10.1016/j.brainres.2010.06.031",
language = "English (US)",
volume = "1349",
pages = "97--104",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",

}

Differential development of central dopaminergic and serotonergic systems in BALB/c and C57BL/6J mice. / Yochum, Carrie L.; Medvecky, Christopher M.; Cheh, Michelle A.; Bhattacharya, Prianka; Wagner, George.

In: Brain research, Vol. 1349, 19.08.2010, p. 97-104.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Differential development of central dopaminergic and serotonergic systems in BALB/c and C57BL/6J mice

AU - Yochum, Carrie L.

AU - Medvecky, Christopher M.

AU - Cheh, Michelle A.

AU - Bhattacharya, Prianka

AU - Wagner, George

PY - 2010/8/19

Y1 - 2010/8/19

N2 - Although the etiology of autism is unclear, disruptions of the dopaminergic and serotonergic systems have been associated with the disorder. Based on behavioral differences observed in the BALB/c strain of mice in comparison to other strains, notably, C57BL/6J mice, it has been suggested that the BALB/c strain may serve as an animal model of autism. However, to date, most work investigating neural and behavioral abnormalities in this strain has been performed in adult animals. Therefore, the present study was conducted to examine the development of the central dopaminergic and serotonergic systems of BALB/c mice as compared to C57BL/6J mice. Levels of dopamine, serotonin, and their metabolites in several different brain regions and at three ages during development were measured. Alterations in both monoaminergic systems associated with age and strain were detected across brain regions indicating that there are neurochemical differences between these strains early in life. However, despite these differences in the development of brain monoaminergic systems, it remains difficult to declare this strain as a valid model of autism.

AB - Although the etiology of autism is unclear, disruptions of the dopaminergic and serotonergic systems have been associated with the disorder. Based on behavioral differences observed in the BALB/c strain of mice in comparison to other strains, notably, C57BL/6J mice, it has been suggested that the BALB/c strain may serve as an animal model of autism. However, to date, most work investigating neural and behavioral abnormalities in this strain has been performed in adult animals. Therefore, the present study was conducted to examine the development of the central dopaminergic and serotonergic systems of BALB/c mice as compared to C57BL/6J mice. Levels of dopamine, serotonin, and their metabolites in several different brain regions and at three ages during development were measured. Alterations in both monoaminergic systems associated with age and strain were detected across brain regions indicating that there are neurochemical differences between these strains early in life. However, despite these differences in the development of brain monoaminergic systems, it remains difficult to declare this strain as a valid model of autism.

UR - http://www.scopus.com/inward/record.url?scp=77955654923&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955654923&partnerID=8YFLogxK

U2 - 10.1016/j.brainres.2010.06.031

DO - 10.1016/j.brainres.2010.06.031

M3 - Article

C2 - 20599834

AN - SCOPUS:77955654923

VL - 1349

SP - 97

EP - 104

JO - Brain Research

JF - Brain Research

SN - 0006-8993

ER -