Differential effect of norepinephrine upon granule cells and interneurons in the dentate gyrus

Greg M. Rose; Kevin C.H. Pang

doi:10.1016/0006-8993(89)90729-4

Differential effect of norepinephrine upon granule cells and interneurons in the dentate gyrus

Greg M. Rose, Kevin C.H. Pang

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The effect of locally applied norepinephrine upon dentate granule cells and neighboring interneurons was examined in urethane-anesthetized rats. Norepinephrine inhibited the spontaneous firing of physiologically identified granule cells, but excited interneurons. These results demonstrate that two coexisting hippocampal cell types, which have many physiological properties and behavioral correlates in common, may be differentiated using a pharmacological criterion.

Original language	English (US)
Pages (from-to)	353-356
Number of pages	4
Journal	Brain research
Volume	488
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(89)90729-4
State	Published - May 29 1989
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

Keywords

Dentate gyrus
Granule cell
Hippocampus
Interneuron
Local application
Neuropharmacology
Norepinephrine

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AU - Pang, Kevin C.H.

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N2 - The effect of locally applied norepinephrine upon dentate granule cells and neighboring interneurons was examined in urethane-anesthetized rats. Norepinephrine inhibited the spontaneous firing of physiologically identified granule cells, but excited interneurons. These results demonstrate that two coexisting hippocampal cell types, which have many physiological properties and behavioral correlates in common, may be differentiated using a pharmacological criterion.

AB - The effect of locally applied norepinephrine upon dentate granule cells and neighboring interneurons was examined in urethane-anesthetized rats. Norepinephrine inhibited the spontaneous firing of physiologically identified granule cells, but excited interneurons. These results demonstrate that two coexisting hippocampal cell types, which have many physiological properties and behavioral correlates in common, may be differentiated using a pharmacological criterion.

KW - Dentate gyrus

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KW - Interneuron

KW - Local application

KW - Neuropharmacology

KW - Norepinephrine

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SN - 0006-8993

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Differential effect of norepinephrine upon granule cells and interneurons in the dentate gyrus

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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