Differential effect of norepinephrine upon granule cells and interneurons in the dentate gyrus

Greg M. Rose; Kevin C.H. Pang

doi:10.1016/0006-8993(89)90729-4

Differential effect of norepinephrine upon granule cells and interneurons in the dentate gyrus

Greg M. Rose, Kevin C.H. Pang

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The effect of locally applied norepinephrine upon dentate granule cells and neighboring interneurons was examined in urethane-anesthetized rats. Norepinephrine inhibited the spontaneous firing of physiologically identified granule cells, but excited interneurons. These results demonstrate that two coexisting hippocampal cell types, which have many physiological properties and behavioral correlates in common, may be differentiated using a pharmacological criterion.

Original language	English (US)
Pages (from-to)	353-356
Number of pages	4
Journal	Brain research
Volume	488
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(89)90729-4
State	Published - May 29 1989
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

Keywords

Dentate gyrus
Granule cell
Hippocampus
Interneuron
Local application
Neuropharmacology
Norepinephrine

Access to Document

10.1016/0006-8993(89)90729-4

Fingerprint Dive into the research topics of 'Differential effect of norepinephrine upon granule cells and interneurons in the dentate gyrus'. Together they form a unique fingerprint.

Cite this

@article{a5f3fe8ca9a34cae98c1b5a960eb8c66,

title = "Differential effect of norepinephrine upon granule cells and interneurons in the dentate gyrus",

abstract = "The effect of locally applied norepinephrine upon dentate granule cells and neighboring interneurons was examined in urethane-anesthetized rats. Norepinephrine inhibited the spontaneous firing of physiologically identified granule cells, but excited interneurons. These results demonstrate that two coexisting hippocampal cell types, which have many physiological properties and behavioral correlates in common, may be differentiated using a pharmacological criterion.",

keywords = "Dentate gyrus, Granule cell, Hippocampus, Interneuron, Local application, Neuropharmacology, Norepinephrine",

author = "Rose, {Greg M.} and Pang, {Kevin C.H.}",

year = "1989",

month = may,

day = "29",

doi = "10.1016/0006-8993(89)90729-4",

language = "English (US)",

volume = "488",

pages = "353--356",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - Differential effect of norepinephrine upon granule cells and interneurons in the dentate gyrus

AU - Rose, Greg M.

AU - Pang, Kevin C.H.

PY - 1989/5/29

Y1 - 1989/5/29

N2 - The effect of locally applied norepinephrine upon dentate granule cells and neighboring interneurons was examined in urethane-anesthetized rats. Norepinephrine inhibited the spontaneous firing of physiologically identified granule cells, but excited interneurons. These results demonstrate that two coexisting hippocampal cell types, which have many physiological properties and behavioral correlates in common, may be differentiated using a pharmacological criterion.

AB - The effect of locally applied norepinephrine upon dentate granule cells and neighboring interneurons was examined in urethane-anesthetized rats. Norepinephrine inhibited the spontaneous firing of physiologically identified granule cells, but excited interneurons. These results demonstrate that two coexisting hippocampal cell types, which have many physiological properties and behavioral correlates in common, may be differentiated using a pharmacological criterion.

KW - Dentate gyrus

KW - Granule cell

KW - Hippocampus

KW - Interneuron

KW - Local application

KW - Neuropharmacology

KW - Norepinephrine

UR - http://www.scopus.com/inward/record.url?scp=0024391678&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024391678&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(89)90729-4

DO - 10.1016/0006-8993(89)90729-4

M3 - Article

C2 - 2743131

AN - SCOPUS:0024391678

VL - 488

SP - 353

EP - 356

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1-2

ER -