Differential effect of norepinephrine upon granule cells and interneurons in the dentate gyrus

Greg M. Rose, Kevin C.H. Pang

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The effect of locally applied norepinephrine upon dentate granule cells and neighboring interneurons was examined in urethane-anesthetized rats. Norepinephrine inhibited the spontaneous firing of physiologically identified granule cells, but excited interneurons. These results demonstrate that two coexisting hippocampal cell types, which have many physiological properties and behavioral correlates in common, may be differentiated using a pharmacological criterion.

Original languageEnglish (US)
Pages (from-to)353-356
Number of pages4
JournalBrain research
Volume488
Issue number1-2
DOIs
StatePublished - May 29 1989
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • Dentate gyrus
  • Granule cell
  • Hippocampus
  • Interneuron
  • Local application
  • Neuropharmacology
  • Norepinephrine

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