Differential effects of chromonar and nitroglycerin on intramyocardial oxygen tension

Harvey R. Weiss; Burton B. Howe; Martin M. Winbury

doi:10.1016/0014-2999(73)90023-X

Differential effects of chromonar and nitroglycerin on intramyocardial oxygen tension

Harvey R. Weiss, Burton B. Howe, Martin M. Winbury

Research output: Contribution to journal › Article

3 Scopus citations

Abstract

Tissue oxygen tension of the subepicardial (Epi Po₂) and subendocardial (Endo Po₂) regions of the canine left ventricular wall was determined polarographically. Chromonar consistently increased Epi Po₂; Endo Po₂ was decreased in half the studies and elevated in the other half. Coronary blood flow was maximally increased by chromonar and reactive hyperemia abolished. Nitroglycerin selectively increased Endo Po₂ before and after chromonar. This suggests that arteriolar dilatation is not a requisite for the rise in Endo Po₂ by nitroglycerin.

Original language	English (US)
Pages (from-to)	249-255
Number of pages	7
Journal	European Journal of Pharmacology
Volume	22
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(73)90023-X
Publication status	Published - Jan 1 1973
Externally published	Yes

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All Science Journal Classification (ASJC) codes

Pharmacology

Keywords

Chromonar
Coronary arteriolar dilation
Distribution of coronary blood flow
Nitroglycerin Intramyocardial Po

Cite this

Weiss, H. R., Howe, B. B., & Winbury, M. M. (1973). Differential effects of chromonar and nitroglycerin on intramyocardial oxygen tension. European Journal of Pharmacology, 22(3), 249-255. https://doi.org/10.1016/0014-2999(73)90023-X

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AU - Winbury, Martin M.

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N2 - Tissue oxygen tension of the subepicardial (Epi Po2) and subendocardial (Endo Po2) regions of the canine left ventricular wall was determined polarographically. Chromonar consistently increased Epi Po2; Endo Po2 was decreased in half the studies and elevated in the other half. Coronary blood flow was maximally increased by chromonar and reactive hyperemia abolished. Nitroglycerin selectively increased Endo Po2 before and after chromonar. This suggests that arteriolar dilatation is not a requisite for the rise in Endo Po2 by nitroglycerin.

AB - Tissue oxygen tension of the subepicardial (Epi Po2) and subendocardial (Endo Po2) regions of the canine left ventricular wall was determined polarographically. Chromonar consistently increased Epi Po2; Endo Po2 was decreased in half the studies and elevated in the other half. Coronary blood flow was maximally increased by chromonar and reactive hyperemia abolished. Nitroglycerin selectively increased Endo Po2 before and after chromonar. This suggests that arteriolar dilatation is not a requisite for the rise in Endo Po2 by nitroglycerin.

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KW - Distribution of coronary blood flow

KW - Nitroglycerin Intramyocardial Po

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10.1016/0014-2999(73)90023-X