Abstract
Tissue oxygen tension of the subepicardial (Epi Po2) and subendocardial (Endo Po2) regions of the canine left ventricular wall was determined polarographically. Chromonar consistently increased Epi Po2; Endo Po2 was decreased in half the studies and elevated in the other half. Coronary blood flow was maximally increased by chromonar and reactive hyperemia abolished. Nitroglycerin selectively increased Endo Po2 before and after chromonar. This suggests that arteriolar dilatation is not a requisite for the rise in Endo Po2 by nitroglycerin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 249-255 |
| Number of pages | 7 |
| Journal | European Journal of Pharmacology |
| Volume | 22 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 1973 |
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All Science Journal Classification (ASJC) codes
- Pharmacology
Keywords
- Chromonar
- Coronary arteriolar dilation
- Distribution of coronary blood flow
- Nitroglycerin Intramyocardial Po
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Differential effects of chromonar and nitroglycerin on intramyocardial oxygen tension. / Weiss, Harvey; Howe, Burton B.; Winbury, Martin M.
In: European Journal of Pharmacology, Vol. 22, No. 3, 01.01.1973, p. 249-255.Research output: Contribution to journal › Article
TY - JOUR
T1 - Differential effects of chromonar and nitroglycerin on intramyocardial oxygen tension
AU - Weiss, Harvey
AU - Howe, Burton B.
AU - Winbury, Martin M.
PY - 1973/1/1
Y1 - 1973/1/1
N2 - Tissue oxygen tension of the subepicardial (Epi Po2) and subendocardial (Endo Po2) regions of the canine left ventricular wall was determined polarographically. Chromonar consistently increased Epi Po2; Endo Po2 was decreased in half the studies and elevated in the other half. Coronary blood flow was maximally increased by chromonar and reactive hyperemia abolished. Nitroglycerin selectively increased Endo Po2 before and after chromonar. This suggests that arteriolar dilatation is not a requisite for the rise in Endo Po2 by nitroglycerin.
AB - Tissue oxygen tension of the subepicardial (Epi Po2) and subendocardial (Endo Po2) regions of the canine left ventricular wall was determined polarographically. Chromonar consistently increased Epi Po2; Endo Po2 was decreased in half the studies and elevated in the other half. Coronary blood flow was maximally increased by chromonar and reactive hyperemia abolished. Nitroglycerin selectively increased Endo Po2 before and after chromonar. This suggests that arteriolar dilatation is not a requisite for the rise in Endo Po2 by nitroglycerin.
KW - Chromonar
KW - Coronary arteriolar dilation
KW - Distribution of coronary blood flow
KW - Nitroglycerin Intramyocardial Po
UR - http://www.scopus.com/inward/record.url?scp=0015786869&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015786869&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(73)90023-X
DO - 10.1016/0014-2999(73)90023-X
M3 - Article
VL - 22
SP - 249
EP - 255
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 3
ER -