Differential effects of chromonar and nitroglycerin on intramyocardial oxygen tension

Harvey Weiss, Burton B. Howe, Martin M. Winbury

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Tissue oxygen tension of the subepicardial (Epi Po2) and subendocardial (Endo Po2) regions of the canine left ventricular wall was determined polarographically. Chromonar consistently increased Epi Po2; Endo Po2 was decreased in half the studies and elevated in the other half. Coronary blood flow was maximally increased by chromonar and reactive hyperemia abolished. Nitroglycerin selectively increased Endo Po2 before and after chromonar. This suggests that arteriolar dilatation is not a requisite for the rise in Endo Po2 by nitroglycerin.

Original languageEnglish (US)
Pages (from-to)249-255
Number of pages7
JournalEuropean Journal of Pharmacology
Volume22
Issue number3
DOIs
StatePublished - Jan 1 1973

Fingerprint

Chromonar
Nitroglycerin
Oxygen
Hyperemia
Canidae
Dilatation

All Science Journal Classification (ASJC) codes

  • Pharmacology

Keywords

  • Chromonar
  • Coronary arteriolar dilation
  • Distribution of coronary blood flow
  • Nitroglycerin Intramyocardial Po

Cite this

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abstract = "Tissue oxygen tension of the subepicardial (Epi Po2) and subendocardial (Endo Po2) regions of the canine left ventricular wall was determined polarographically. Chromonar consistently increased Epi Po2; Endo Po2 was decreased in half the studies and elevated in the other half. Coronary blood flow was maximally increased by chromonar and reactive hyperemia abolished. Nitroglycerin selectively increased Endo Po2 before and after chromonar. This suggests that arteriolar dilatation is not a requisite for the rise in Endo Po2 by nitroglycerin.",
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Differential effects of chromonar and nitroglycerin on intramyocardial oxygen tension. / Weiss, Harvey; Howe, Burton B.; Winbury, Martin M.

In: European Journal of Pharmacology, Vol. 22, No. 3, 01.01.1973, p. 249-255.

Research output: Contribution to journalArticle

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AU - Howe, Burton B.

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AB - Tissue oxygen tension of the subepicardial (Epi Po2) and subendocardial (Endo Po2) regions of the canine left ventricular wall was determined polarographically. Chromonar consistently increased Epi Po2; Endo Po2 was decreased in half the studies and elevated in the other half. Coronary blood flow was maximally increased by chromonar and reactive hyperemia abolished. Nitroglycerin selectively increased Endo Po2 before and after chromonar. This suggests that arteriolar dilatation is not a requisite for the rise in Endo Po2 by nitroglycerin.

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KW - Nitroglycerin Intramyocardial Po

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