Differential effects of prenatal morphine exposure on analgesia produced by vaginocervical stimulation or systemic morphine administration in adult rats

Ilona Vathy, Barry R. Komisaruk

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The present study investigated the effects of prenatal morphine exposure on the magnitude of analgesia produced by vaginocervical stimulation (VS) or systemic morphine injection in adult rats. In Experiment 1, an acute subcutaneous morphine (1 mg/kg) injection induced a 124% greater increase in tail-flick latency (TFL) in adult rats exposed prenatally to saline than to morphine. By contrast, in Experiment 2, VS induced a 196% greater increase in TFL in adult rats exposed prenatally to morphine than to saline. Female rats exposed prenatally to morphine also had a greater VS-produced increase in vocalization threshold (VOC-T) to tail shock than those exposed prenatally to saline. Thus, the present study demonstrates that prenatal morphine exposure exerts diametrically opposite effects on analgesia that is produced in adulthood by morphine or VS, attenuating the former while potentiating the latter. These findings provide evidence that the mechanisms underlying the two types of analgesia differ fundamentally.

Original languageEnglish (US)
Pages (from-to)165-170
Number of pages6
JournalPharmacology Biochemistry and Behavior
Volume72
Issue number1-2
DOIs
StatePublished - 2002

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Keywords

  • Morphine- and VS-induced analgesia
  • Prenatal morphine exposure

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