Differential monocyte activation underlies strain-specific Mycobacterium tuberculosis pathogenesis

Claudia Manca; Michael B. Reed; Sherry Freeman; Barun Mathema; Barry Kreiswirth; Clifton E. Barry; Gilla Kaplan

doi:10.1128/IAI.72.9.5511-5514.2004

Differential monocyte activation underlies strain-specific Mycobacterium tuberculosis pathogenesis

Claudia Manca, Michael B. Reed, Sherry Freeman, Barun Mathema, Barry Kreiswirth, Clifton E. Barry, Gilla Kaplan

Research output: Contribution to journal › Article › peer-review

176 Scopus citations

Abstract

In vitro infection of monocytes with Mycobacterium tuberculosis HN878 and related W/Beijing isolates preferentially induced inierleukin-4 (IL-4) and IL-13, which characterize Th2 polarized immunity. In contrast, CDC1551 induced more IL-12 and other molecules associated with phagocyte activation and Th1 protective immunity. The differential cytokine-chemokine response was mediated by extracted lipids, suggesting that these molecules regulate host responses to infection.

Original language	English (US)
Pages (from-to)	5511-5514
Number of pages	4
Journal	Infection and immunity
Volume	72
Issue number	9
DOIs	https://doi.org/10.1128/IAI.72.9.5511-5514.2004
State	Published - Sep 2004
Externally published	Yes

All Science Journal Classification (ASJC) codes

Parasitology
Microbiology
Immunology
Infectious Diseases

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abstract = "In vitro infection of monocytes with Mycobacterium tuberculosis HN878 and related W/Beijing isolates preferentially induced inierleukin-4 (IL-4) and IL-13, which characterize Th2 polarized immunity. In contrast, CDC1551 induced more IL-12 and other molecules associated with phagocyte activation and Th1 protective immunity. The differential cytokine-chemokine response was mediated by extracted lipids, suggesting that these molecules regulate host responses to infection.",

author = "Claudia Manca and Reed, {Michael B.} and Sherry Freeman and Barun Mathema and Barry Kreiswirth and Barry, {Clifton E.} and Gilla Kaplan",

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AU - Reed, Michael B.

AU - Freeman, Sherry

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AU - Kreiswirth, Barry

AU - Barry, Clifton E.

AU - Kaplan, Gilla

PY - 2004/9

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AB - In vitro infection of monocytes with Mycobacterium tuberculosis HN878 and related W/Beijing isolates preferentially induced inierleukin-4 (IL-4) and IL-13, which characterize Th2 polarized immunity. In contrast, CDC1551 induced more IL-12 and other molecules associated with phagocyte activation and Th1 protective immunity. The differential cytokine-chemokine response was mediated by extracted lipids, suggesting that these molecules regulate host responses to infection.

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