Differential monocyte activation underlies strain-specific Mycobacterium tuberculosis pathogenesis

Claudia Manca, Michael B. Reed, Sherry Freeman, Barun Mathema, Barry Kreiswirth, Clifton E. Barry, Gilla Kaplan

Research output: Contribution to journalArticlepeer-review

176 Scopus citations


In vitro infection of monocytes with Mycobacterium tuberculosis HN878 and related W/Beijing isolates preferentially induced inierleukin-4 (IL-4) and IL-13, which characterize Th2 polarized immunity. In contrast, CDC1551 induced more IL-12 and other molecules associated with phagocyte activation and Th1 protective immunity. The differential cytokine-chemokine response was mediated by extracted lipids, suggesting that these molecules regulate host responses to infection.

Original languageEnglish (US)
Pages (from-to)5511-5514
Number of pages4
JournalInfection and immunity
Issue number9
StatePublished - Sep 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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