Differential p53, p21, mdm2 and Rb regulation in glioma cell lines that overexpress wild-type p53

Mark J. Pykett, Edouard Azzam, William Dahlberg, John B. Little

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Gliomas are part of a subset of tumors in which overexpression of p53 protein in the absence of p53 gene mutation has been described. We have utilized a series of glioma cell lines to study the effects of ionizing radiation on the regulation of p53, p21, mdm2 and Rb proteins. The induction of p53 protein in glioma cell lines that overexpress wild-type p53 differs from normal control cells and glioma cell lines containing mutant p53. Alterations in the accumulation of p53 and p21 proteins are associated with diminished Rb hypophosphorylation. Gliomas that overexpress wild-type p53 also express high levels of mdm2 protein and exhibit a radiosensitivity that is intermediate between normal cells and cells with mutant p53. These findings suggest that, at least in certain glioma cell lines that over- express p53 which is wild-type in sequence, the function of p53 protein is abnormal.

Original languageEnglish (US)
Pages (from-to)213-216
Number of pages4
JournalInternational journal of oncology
Volume13
Issue number2
DOIs
StatePublished - Aug 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Keywords

  • Gliomas
  • Irradiation
  • Rb
  • mdm2
  • p21
  • p53

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