Differentiating stem cells into liver

Alejandro Soto-Gutierrez, Hesham Basma, Nalu Navarro-Alvarez, Basak E. Uygun, Martin L. Yarmush, Naoya Kobayashi, Ira J. Fox

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Research involving differentiated embryonic stem (ES) cells may revolutionize the study of liver disease, improve the drug discovery process, and assist in the development of stem-cell-based clinical therapies. Generation of ES cell-derived hepatic tissue has benefited from an understanding of the cytokines, growth factors and biochemical compounds that are essential in liver development, and this knowledge has been used to mimic some aspects of embryonic development in vitro. Although great progress has been made in differentiating human ES cells into liver cells, current protocols have not yet produced cells with the phenotype of a mature hepatocyte. There is a of disease models have been examined concerning whether stem cells can correct liver disease. It is a bit premature to conclude that hepatocytes can be generated from non-hepatic cells in culture that will be clinically useful. Standard criteria will need to be developed to assess the extent to which human stem cell-derived hepatocytes have been produced.

Original languageEnglish (US)
Pages (from-to)149-164
Number of pages16
JournalBiotechnology and Genetic Engineering Reviews
Volume25
Issue number1
DOIs
StatePublished - Jan 1 2008

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Stem cells
Liver
Hepatocytes
Stem Cells
Embryonic Stem Cells
Liver Diseases
Drug Discovery
Embryonic Development
Intercellular Signaling Peptides and Proteins
Cell Culture Techniques
Cytokines
Phenotype
Research
Tissue
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Molecular Biology

Cite this

Soto-Gutierrez, A., Basma, H., Navarro-Alvarez, N., Uygun, B. E., Yarmush, M. L., Kobayashi, N., & Fox, I. J. (2008). Differentiating stem cells into liver. Biotechnology and Genetic Engineering Reviews, 25(1), 149-164. https://doi.org/10.5661/bger-25-149
Soto-Gutierrez, Alejandro ; Basma, Hesham ; Navarro-Alvarez, Nalu ; Uygun, Basak E. ; Yarmush, Martin L. ; Kobayashi, Naoya ; Fox, Ira J. / Differentiating stem cells into liver. In: Biotechnology and Genetic Engineering Reviews. 2008 ; Vol. 25, No. 1. pp. 149-164.
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Soto-Gutierrez, A, Basma, H, Navarro-Alvarez, N, Uygun, BE, Yarmush, ML, Kobayashi, N & Fox, IJ 2008, 'Differentiating stem cells into liver', Biotechnology and Genetic Engineering Reviews, vol. 25, no. 1, pp. 149-164. https://doi.org/10.5661/bger-25-149

Differentiating stem cells into liver. / Soto-Gutierrez, Alejandro; Basma, Hesham; Navarro-Alvarez, Nalu; Uygun, Basak E.; Yarmush, Martin L.; Kobayashi, Naoya; Fox, Ira J.

In: Biotechnology and Genetic Engineering Reviews, Vol. 25, No. 1, 01.01.2008, p. 149-164.

Research output: Contribution to journalArticle

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Soto-Gutierrez A, Basma H, Navarro-Alvarez N, Uygun BE, Yarmush ML, Kobayashi N et al. Differentiating stem cells into liver. Biotechnology and Genetic Engineering Reviews. 2008 Jan 1;25(1):149-164. https://doi.org/10.5661/bger-25-149