The use of digitalis after acute myocardial infarction is controversial. The effect of digoxin on computer-quantitated thallium-201 perfusion scintigrams (Tl-201), left ventricular (LV) ejection fraction (EF), and percentage of abnormally contracting LV regions (%ACR) was determined in 23 patients. A correlation was established between creatine kinase MB isoenzyme release and initial radionuclide-gated blood pool wall motion estimates of EF (r=-0.73) and %ACR (r=0.71). After radionuclide assessments, 14 patients received digoxin 18 ± 23 hours (mean ± SD) after the rise in CK-MB from baseline, while the remaining nine patients served as controls. In the control group, the mean EF was 0.33 ± 0.12 on the first study and 0.30 ± 0.08 on the second study (p = NS). In the digoxin group, the EF after digoxin administration (mean 0.33 ± 0.11) was significantly different from the initial EF (mean 0.29 ± 0.09, p<0.03); however, digoxin had no apparent effect on infarct size as assessed by sequential %ACR and Tl-201 perfusion data. These data indicate that digoxin resulted in a minimal but significant improvement in EF that did not occur at the expense of LV perfusion or regional wall motion.
All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
- Physiology (medical)