Digitalis and myocardial infarction in man

J. Morrison, J. Coromilas, M. Robbins, L. Ong, S. Eisenberg, R. Stechel, M. Zema, P. Reiser, L. Scherr

Research output: Contribution to journalArticle

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Abstract

The use of digitalis after acute myocardial infarction is controversial. The effect of digoxin on computer-quantitated thallium-201 perfusion scintigrams (Tl-201), left ventricular (LV) ejection fraction (EF), and percentage of abnormally contracting LV regions (%ACR) was determined in 23 patients. A correlation was established between creatine kinase MB isoenzyme release and initial radionuclide-gated blood pool wall motion estimates of EF (r=-0.73) and %ACR (r=0.71). After radionuclide assessments, 14 patients received digoxin 18 ± 23 hours (mean ± SD) after the rise in CK-MB from baseline, while the remaining nine patients served as controls. In the control group, the mean EF was 0.33 ± 0.12 on the first study and 0.30 ± 0.08 on the second study (p = NS). In the digoxin group, the EF after digoxin administration (mean 0.33 ± 0.11) was significantly different from the initial EF (mean 0.29 ± 0.09, p<0.03); however, digoxin had no apparent effect on infarct size as assessed by sequential %ACR and Tl-201 perfusion data. These data indicate that digoxin resulted in a minimal but significant improvement in EF that did not occur at the expense of LV perfusion or regional wall motion.

Original languageEnglish (US)
Pages (from-to)8-16
Number of pages9
JournalCirculation
Volume62
Issue number1
DOIs
StatePublished - Jan 1 1980

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Digitalis
Digoxin
Myocardial Infarction
Perfusion
Thallium
Radioisotopes
MB Form Creatine Kinase
Stroke Volume
Isoenzymes
Control Groups

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Morrison, J., Coromilas, J., Robbins, M., Ong, L., Eisenberg, S., Stechel, R., ... Scherr, L. (1980). Digitalis and myocardial infarction in man. Circulation, 62(1), 8-16. https://doi.org/10.1161/01.CIR.62.1.8
Morrison, J. ; Coromilas, J. ; Robbins, M. ; Ong, L. ; Eisenberg, S. ; Stechel, R. ; Zema, M. ; Reiser, P. ; Scherr, L. / Digitalis and myocardial infarction in man. In: Circulation. 1980 ; Vol. 62, No. 1. pp. 8-16.
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Morrison, J, Coromilas, J, Robbins, M, Ong, L, Eisenberg, S, Stechel, R, Zema, M, Reiser, P & Scherr, L 1980, 'Digitalis and myocardial infarction in man', Circulation, vol. 62, no. 1, pp. 8-16. https://doi.org/10.1161/01.CIR.62.1.8

Digitalis and myocardial infarction in man. / Morrison, J.; Coromilas, J.; Robbins, M.; Ong, L.; Eisenberg, S.; Stechel, R.; Zema, M.; Reiser, P.; Scherr, L.

In: Circulation, Vol. 62, No. 1, 01.01.1980, p. 8-16.

Research output: Contribution to journalArticle

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AU - Zema, M.

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Morrison J, Coromilas J, Robbins M, Ong L, Eisenberg S, Stechel R et al. Digitalis and myocardial infarction in man. Circulation. 1980 Jan 1;62(1):8-16. https://doi.org/10.1161/01.CIR.62.1.8