TY - JOUR
T1 - Dioxins and Dibenzofurans in Blood and Adipose Tissue of Agent Orange—Exposed Vietnam Veterans and Matched Controls
AU - Kahn, Peter C.
AU - Gochfeld, Michael
AU - Nygren, Martin
AU - Hansson, Marianne
AU - Rappe, Christoffer
AU - Velez, Henry
AU - Ghent Guenther, Therese
AU - Wilson, Wayne P.
PY - 1988/3/18
Y1 - 1988/3/18
N2 - Vietnam veterans who were heavily exposed to Agent Orange exceeded matched control subjects in both blood and adipose tissue levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) but not in the levels of the 12 other 2,3,7,8-substituted dioxins and dibenzofurans that were detected. Since only TCDD among these compounds was present in Agent Orange but all are present in the population of the industrialized world, it is likely that the elevated TCDD levels arose from wartime exposure. The high correlation (r= +.89) of blood with adipose tissue level suggests that there may be a mobile equilibrium between them and that blood measurement could replace adipose tissue measurement of TCDD levels, making the collection of human data less invasive.
AB - Vietnam veterans who were heavily exposed to Agent Orange exceeded matched control subjects in both blood and adipose tissue levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) but not in the levels of the 12 other 2,3,7,8-substituted dioxins and dibenzofurans that were detected. Since only TCDD among these compounds was present in Agent Orange but all are present in the population of the industrialized world, it is likely that the elevated TCDD levels arose from wartime exposure. The high correlation (r= +.89) of blood with adipose tissue level suggests that there may be a mobile equilibrium between them and that blood measurement could replace adipose tissue measurement of TCDD levels, making the collection of human data less invasive.
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U2 - 10.1001/jama.1988.03720110023029
DO - 10.1001/jama.1988.03720110023029
M3 - Article
C2 - 3343772
AN - SCOPUS:0023930644
SN - 0098-7484
VL - 259
SP - 1661
EP - 1667
JO - JAMA: The Journal of the American Medical Association
JF - JAMA: The Journal of the American Medical Association
IS - 11
ER -