Dioxins and Dibenzofurans in Blood and Adipose Tissue of Agent Orange—Exposed Vietnam Veterans and Matched Controls

Peter Kahn, Michael Gochfeld, Martin Nygren, Marianne Hansson, Christoffer Rappe, Henry Velez, Therese Ghent Guenther, Wayne P. Wilson

Research output: Contribution to journalArticlepeer-review

100 Scopus citations

Abstract

Vietnam veterans who were heavily exposed to Agent Orange exceeded matched control subjects in both blood and adipose tissue levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) but not in the levels of the 12 other 2,3,7,8-substituted dioxins and dibenzofurans that were detected. Since only TCDD among these compounds was present in Agent Orange but all are present in the population of the industrialized world, it is likely that the elevated TCDD levels arose from wartime exposure. The high correlation (r= +.89) of blood with adipose tissue level suggests that there may be a mobile equilibrium between them and that blood measurement could replace adipose tissue measurement of TCDD levels, making the collection of human data less invasive.

Original languageEnglish (US)
Pages (from-to)1661-1667
Number of pages7
JournalJAMA: The Journal of the American Medical Association
Volume259
Issue number11
DOIs
StatePublished - Mar 18 1988

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Fingerprint Dive into the research topics of 'Dioxins and Dibenzofurans in Blood and Adipose Tissue of Agent Orange—Exposed Vietnam Veterans and Matched Controls'. Together they form a unique fingerprint.

Cite this