TY - JOUR
T1 - Directional solidification of collagen-based aqueous solutions to develop porous biomaterials
AU - Berthiaume, Francois
AU - Hsiao, Paul
AU - Tompkins, Ronald G.
AU - Yarmush, Martin L.
AU - Toner, Mehmet
N1 - Funding Information:
Thanks to David and Louise Powick for providing data for their farm. We acknowledge the financial support of Dairy InSight (project 10079) and Foundation for Research Science and Technology (project DRCX0301).
PY - 1994
Y1 - 1994
N2 - Freeze-drying is an efficient way of controlling the microgeometry (i.e. pore size and orientation) during synthesis of biomaterials. In the present study, we investigated the morphology of ice crystal growth in a microscopy directional solidification stage system using collagen-based aqueous solutions. We found that the size of ice crystals growing at steady state was highly dependent on the composition of the solution, temperature gradient, and solid-liquid interface velocity. By carefully choosing these parameters, it was possible to create ice crystal sizes, with lattice spacings between 50 and 100 μm. This lattice spacing would be suitable for cell-based applications after sublimation of the ice to create pores.
AB - Freeze-drying is an efficient way of controlling the microgeometry (i.e. pore size and orientation) during synthesis of biomaterials. In the present study, we investigated the morphology of ice crystal growth in a microscopy directional solidification stage system using collagen-based aqueous solutions. We found that the size of ice crystals growing at steady state was highly dependent on the composition of the solution, temperature gradient, and solid-liquid interface velocity. By carefully choosing these parameters, it was possible to create ice crystal sizes, with lattice spacings between 50 and 100 μm. This lattice spacing would be suitable for cell-based applications after sublimation of the ice to create pores.
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M3 - Conference article
AN - SCOPUS:0028735794
SN - 0272-5673
VL - 288
SP - 109
EP - 110
JO - American Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD
JF - American Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD
T2 - Proceedings of the 1994 International Mechanical Engineering Congress and Exposition
Y2 - 6 November 1994 through 11 November 1994
ER -