Directional solidification of collagen-based aqueous solutions to develop porous biomaterials

Francois Berthiaume, Paul Hsiao, Ronald G. Tompkins, Martin L. Yarmush, Mehmet Toner

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations


Freeze-drying is an efficient way of controlling the microgeometry (i.e. pore size and orientation) during synthesis of biomaterials. In the present study, we investigated the morphology of ice crystal growth in a microscopy directional solidification stage system using collagen-based aqueous solutions. We found that the size of ice crystals growing at steady state was highly dependent on the composition of the solution, temperature gradient, and solid-liquid interface velocity. By carefully choosing these parameters, it was possible to create ice crystal sizes, with lattice spacings between 50 and 100 μm. This lattice spacing would be suitable for cell-based applications after sublimation of the ice to create pores.

Original languageEnglish (US)
Pages (from-to)109-110
Number of pages2
JournalAmerican Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD
StatePublished - 1994
Externally publishedYes
EventProceedings of the 1994 International Mechanical Engineering Congress and Exposition - Chicago, IL, USA
Duration: Nov 6 1994Nov 11 1994

All Science Journal Classification (ASJC) codes

  • Mechanical Engineering
  • Fluid Flow and Transfer Processes


Dive into the research topics of 'Directional solidification of collagen-based aqueous solutions to develop porous biomaterials'. Together they form a unique fingerprint.

Cite this