Discrete element modeling of solid dosage manufacturing processes

Dana Barrasso, Rohit Ramachandran

Research output: Chapter in Book/Report/Conference proceedingChapter


Solid dosage manufacturing primarily involves powder process operations, such as mixing, granulation, and compaction. A model-based approach can be used to develop a better scientific understanding of these processes and implement Quality by Design. These models must predict the critical quality attributes of the product based on process parameters, equipment geometry, and material properties. Discrete element modeling (DEM) is often used to capture mechanistic, particle-scale information, such as velocity and force profiles. In this chapter, recent literature studies that use the DEM to model solid dosage manufacturing processes will be presented and discussed.

Original languageEnglish (US)
Title of host publicationMethods in Pharmacology and Toxicology
PublisherHumana Press Inc.
Number of pages27
StatePublished - Jan 1 2016

Publication series

NameMethods in Pharmacology and Toxicology
ISSN (Print)1557-2153
ISSN (Electronic)1940-6053

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)


  • Discrete element modeling
  • Multi-scale modeling
  • Particulate processes
  • Quality by Design
  • Solid dosage manufacturing


Dive into the research topics of 'Discrete element modeling of solid dosage manufacturing processes'. Together they form a unique fingerprint.

Cite this