Solid dosage manufacturing primarily involves powder process operations, such as mixing, granulation, and compaction. A model-based approach can be used to develop a better scientific understanding of these processes and implement Quality by Design. These models must predict the critical quality attributes of the product based on process parameters, equipment geometry, and material properties. Discrete element modeling (DEM) is often used to capture mechanistic, particle-scale information, such as velocity and force profiles. In this chapter, recent literature studies that use the DEM to model solid dosage manufacturing processes will be presented and discussed.