Disorders of the Adrenal Cortex in the Fetus and Neonate

Ahmed Khattab; Mithra L. Narasimhan; Anne Macdonald; Gertrude Costin; Maria New

doi:10.1016/B978-0-12-814823-5.00048-9

Disorders of the Adrenal Cortex in the Fetus and Neonate

Ahmed Khattab, Mithra L. Narasimhan, Anne Macdonald, Gertrude Costin, Maria New

Robert Wood Johnson Medical School (RWJMS), Pediatrics, Division of Endocrinology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

The clinical signs, symptoms, and hormonal abnormalities of adrenal cortex disorder are dictated by the degree of involvement of the mineralocorticoid, glucocorticoid, and sex hormone pathways secreted by the zona glomerulosa, zona fasciculata, and zona reticularis, respectively. The causal genetic mutations leading to many adrenal disorders have been identified. Careful interpretation of clinical, hormonal, and genetic data assists in reaching an accurate diagnosis. This chapter describes genetic adrenocortical disorders of neonatal and fetal onset, including syndromic adrenal disorders.

Original language	English (US)
Title of host publication	Maternal-Fetal and Neonatal Endocrinology
Subtitle of host publication	Physiology, Pathophysiology, and Clinical Management
Publisher	Elsevier
Pages	813-839
Number of pages	27
ISBN (Electronic)	9780128148235
ISBN (Print)	9780128148242
DOIs	https://doi.org/10.1016/B978-0-12-814823-5.00048-9
State	Published - Jan 1 2020

All Science Journal Classification (ASJC) codes

General Medicine

Keywords

Adrenal insufficiency
Androgens
Genetics
Glucocorticoid
Mineralocorticoid

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10.1016/B978-0-12-814823-5.00048-9

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KW - Genetics

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KW - Mineralocorticoid

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Disorders of the Adrenal Cortex in the Fetus and Neonate

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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