Dissecting transcriptional control networks

Vijayalakshmi H. Nagaraj, Anirvan M. Sengupta

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Reconstructing how transcriptional networks function involves figuring out which promoters are affected by which transcription factors. Searching for functional regulatory sites bound by particular transcription factors in a genome is therefore of great importance. The chapter discusses efforts at building classifiers that separate promoters targeted by particular transcription factors from those that are not. We start with simple sequence classifiers based on Support Vector Machines and go on to discuss how to integrate different kind of data into the analysis.

Original languageEnglish (US)
Title of host publicationIntroduction to Systems Biology
PublisherHumana Press
Pages106-123
Number of pages18
ISBN (Print)9781588297068
DOIs
StatePublished - 2007

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Keywords

  • DNA sequence
  • Transcription
  • evolution
  • motifs
  • probabilistic models
  • regulatory elements
  • support vector machines

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