Dissociating medial temporal and basal ganglia memory systems with a latent learning task

Catherine E. Myers, Daphna Shohamy, Mark A. Gluck, Steven Grossman, Somporn Onlaor, Narinder Kapur

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

The medial temporal (MT) lobes and basal ganglia have both been implicated as brain substrates of associative learning. Here, we show a dissociation between medial temporal and basal ganglia damage using a latent learning task, in which prior exposure to cues, uncorrelated with each other, slows subsequent learning of an association between them. Consistent with prior work, we found a robust exposure effect in healthy controls, with exposed controls learning more slowly than non-exposed controls. This effect was abolished in medial temporal amnesia: both exposed and non-exposed amnesic patients learned at the same speed. A group of patients with basal ganglia damage due to Parkinson's disease showed a reversal of the effect: exposed subjects learned faster than non-exposed subjects. Our findings point to distinct and dissociable contributions of medial temporal lobe and basal ganglia structures to learning and memory.

Original languageEnglish (US)
Pages (from-to)1919-1928
Number of pages10
JournalNeuropsychologia
Volume41
Issue number14
DOIs
StatePublished - 2003

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Keywords

  • Amnesia
  • Hippocampus
  • Learned irrelevance
  • Memory
  • Parkinson's disease
  • Perceptual learning

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