Dissociating Medial Temporal and Striatal Memory Systems With a Same/Different Matching Task: Evidence for Two Neural Systems in Human Recognition

Neha Sinha, Arnold Lewis Glass

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The medial temporal lobe and striatum have both been implicated as brain substrates of memory and learning. Here, we show dissociation between these two memory systems using a same/different matching task, in which subjects judged whether four-letter strings were the same or different. Different RT was determined by the left-to-right location of the first letter different between the study and test string, consistent with a left-to-right comparison of the study and test strings, terminating when a difference was found. This comparison process results in same responses being slower than different responses. Nevertheless, same responses were faster than different responses. Same responses were associated with hippocampus activation. Different responses were associated with both caudate and hippocampus activation. These findings are consistent with the dual-system hypothesis of mammalian memory and extend the model to human visual recognition.

Original languageEnglish (US)
Pages (from-to)110-129
Number of pages20
JournalJournal of General Psychology
Volume144
Issue number2
DOIs
StatePublished - Apr 3 2017

All Science Journal Classification (ASJC) codes

  • Gender Studies
  • Experimental and Cognitive Psychology
  • Arts and Humanities (miscellaneous)

Keywords

  • Cognition
  • memory
  • neuroimaging
  • reaction time

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