Dissolution testing of single-and dual-component thyroid hormone supplements

Samantha L. Bowerbank; Michelle G. Carlin; John R. Dean

doi:10.3390/separations6010018

Dissolution testing of single-and dual-component thyroid hormone supplements

Samantha L. Bowerbank, Michelle G. Carlin, John R. Dean

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A method for the analysis of thyroid hormones by liquid chromatography-mass spectrometry was used for the dissolution testing of single-and dual-component thyroid hormone supplements via a two-stage biorelevant dissolution procedure. The biorelevant media consisted of fasted-state simulated gastric fluid and fasted state simulated intestinal fluid at 37^◦ C, and was investigated using an internationally recognized protocol. The dissolution profiles showed consistent solubilization for both single-and dual-component batches at pH 6.5 in the fasted-state simulated intestinal fluid.

Original language	English (US)
Article number	18
Journal	Separations
Volume	6
Issue number	1
DOIs	https://doi.org/10.3390/separations6010018
State	Published - Mar 2019
Externally published	Yes

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Filtration and Separation

Keywords

Dissolution
Liquid chromatography-mass spectrometry
Thyroid

Access to Document

10.3390/separations6010018

Cite this

@article{cdf772081266486fa0458a69dcc7320a,

title = "Dissolution testing of single-and dual-component thyroid hormone supplements",

abstract = "A method for the analysis of thyroid hormones by liquid chromatography-mass spectrometry was used for the dissolution testing of single-and dual-component thyroid hormone supplements via a two-stage biorelevant dissolution procedure. The biorelevant media consisted of fasted-state simulated gastric fluid and fasted state simulated intestinal fluid at 37◦ C, and was investigated using an internationally recognized protocol. The dissolution profiles showed consistent solubilization for both single-and dual-component batches at pH 6.5 in the fasted-state simulated intestinal fluid.",

keywords = "Dissolution, Liquid chromatography-mass spectrometry, Thyroid",

author = "Bowerbank, {Samantha L.} and Carlin, {Michelle G.} and Dean, {John R.}",

note = "Funding Information: We acknowledge GlaxoSmithKline for the donation of the dissolution bath to Northumbria University. We also gratefully acknowledge financial support from Northumbria University. Publisher Copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2019",

month = mar,

doi = "10.3390/separations6010018",

language = "English (US)",

volume = "6",

journal = "Separations",

issn = "2297-8739",

publisher = "Multidisciplinary Digital Publishing Institute",

number = "1",

}

TY - JOUR

T1 - Dissolution testing of single-and dual-component thyroid hormone supplements

AU - Bowerbank, Samantha L.

AU - Carlin, Michelle G.

AU - Dean, John R.

N1 - Funding Information: We acknowledge GlaxoSmithKline for the donation of the dissolution bath to Northumbria University. We also gratefully acknowledge financial support from Northumbria University. Publisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2019/3

Y1 - 2019/3

N2 - A method for the analysis of thyroid hormones by liquid chromatography-mass spectrometry was used for the dissolution testing of single-and dual-component thyroid hormone supplements via a two-stage biorelevant dissolution procedure. The biorelevant media consisted of fasted-state simulated gastric fluid and fasted state simulated intestinal fluid at 37◦ C, and was investigated using an internationally recognized protocol. The dissolution profiles showed consistent solubilization for both single-and dual-component batches at pH 6.5 in the fasted-state simulated intestinal fluid.

AB - A method for the analysis of thyroid hormones by liquid chromatography-mass spectrometry was used for the dissolution testing of single-and dual-component thyroid hormone supplements via a two-stage biorelevant dissolution procedure. The biorelevant media consisted of fasted-state simulated gastric fluid and fasted state simulated intestinal fluid at 37◦ C, and was investigated using an internationally recognized protocol. The dissolution profiles showed consistent solubilization for both single-and dual-component batches at pH 6.5 in the fasted-state simulated intestinal fluid.

KW - Dissolution

KW - Liquid chromatography-mass spectrometry

KW - Thyroid

UR - http://www.scopus.com/inward/record.url?scp=85070224172&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070224172&partnerID=8YFLogxK

U2 - 10.3390/separations6010018

DO - 10.3390/separations6010018

M3 - Article

AN - SCOPUS:85070224172

SN - 2297-8739

VL - 6

JO - Separations

JF - Separations

IS - 1

M1 - 18

ER -

Dissolution testing of single-and dual-component thyroid hormone supplements

Abstract

All Science Journal Classification (ASJC) codes

Keywords

Access to Document

Other files and links

Fingerprint

Cite this