Distinct types of T-cell help for the induction of a humoral immune response to Streptococcus pneumoniae

Clifford M. Snapper, Yi Shen, Abdul Q. Khan, Jesus Colino, Piotr Zelazowski, James J. Mond, William C. Gause, Zheng Qi Wu

Research output: Contribution to journalReview article

35 Scopus citations

Abstract

Studies have indicated that purified soluble polysaccharide antigens can elicit T cell-independent Ig responses in vivo, although these responses can be modulated by T cells in a noncognate manner. Relatively little is known, however, concerning the parameters that regulate polysaccharide-specific, as well as protein-specific, Ig isotype responses to an intact extracellular bacterium. Using the murine in vivo humoral response to intact Streptococcus pneumoniae as a model it can be shown that CD4+ T-cell receptor αβ+ T cells deliver help for both polysaccharide- and protein-specific Ig responses. However, these responses differ fundamentally in their mechanism of action.

Original languageEnglish (US)
Pages (from-to)308-311
Number of pages4
JournalTrends in Immunology
Volume22
Issue number6
DOIs
StatePublished - Aug 4 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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