Distribution of efferent cholinergic terminals and α-bungarotoxin binding to putative nicotinic acetylcholine receptors in the human vestibular end-organs

Akira Ishiyama, Ivan Lopez, Phillip A. Wackym

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Although acetylcholine (ACh) has been identified as the primary neurotransmitter of the efferent vestibular system in most animals studied, no direct evidence exists that ACh is the efferent neurotransmitter of the human vestibular system. Choline acetyltransferase immunohistochemistry (ChATi), acetylcholinesterase (AChE) histochemistry, and a-bungarotoxin binding were used in human vestibular end-organs to address this question. ChATi and AChE activity was found in numerous bouton-type terminals contacting the basal area of type II vestibular hair cells and the afferent chalices surrounding type I hair cells; a-bungarotoxin binding suggested the presence of nicotinic acetylcholine receptors on type II vestibular hair cells and on the afferent chalices surrounding type I hair cells. This study provides evidence that the human efferent vestibular axons and terminals are cholinergic and that the receptors receiving this innervation may be nicotinic.

Original languageEnglish (US)
Pages (from-to)1167-1172
Number of pages6
JournalLaryngoscope
Volume105
Issue number11
DOIs
StatePublished - Nov 1995

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Fingerprint

Dive into the research topics of 'Distribution of efferent cholinergic terminals and α-bungarotoxin binding to putative nicotinic acetylcholine receptors in the human vestibular end-organs'. Together they form a unique fingerprint.

Cite this