Diverse expression patterns of lim-homeodomain transcription factors (LIM-HDs) in mammalian inner ear development

Mingqian Huang, Cyrille Sage, Huawei Li, Mengquig Xiang, Stefan Heller, Zheng Yi Chen

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

LIM-homeodomain transcription factors (LIM-HDs) are essential in tissue patterning and differentiation. But their expression patterns in the inner ear are largely unknown. Here we report on a study of twelve LIM-HDs, by their tempo-spatial patterns that imply distinct yet overlapping roles, in the developing mouse inner ear. Expression of Lmx1a and Isl1 begins in the otocyst stage, with Lmx1a exclusively in the non-sensory and Isl1 in the prosensory epithelia. The second wave of expression at E12.5 includes Lhx3, 5, 9, Isl2, and Lmx1b in the differentiating sensory epithelia with cellular specificities. With the exception of Lmx1a and Lhx3, all LIM-HDs are expressed in ganglion neurons. Expression of multiple LIM-HDs within a cell type suggests their redundant function.

Original languageEnglish (US)
Pages (from-to)3305-3312
Number of pages8
JournalDevelopmental Dynamics
Volume237
Issue number11
DOIs
StatePublished - Nov 2008

All Science Journal Classification (ASJC) codes

  • Developmental Biology

Keywords

  • Development
  • Differentiation
  • Hair cells
  • Inner ear
  • LIM-HD

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