DNA associations: Packing calculations in A-, B-, and Z-DNA structures

A. R. Srinivasan, Wilma K. Olson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A detailed theoretical study is carried out to understand the modes of DNA-DNA interactions on the basis of hard sphere contact criteria. The results show that the helices of identical structure and length are oriented side-by-side and their relative positions are controlled by translations along and rotations about specific axes. Short atomic contacts between the pairs of atoms in the structures are assessed and the contact-free conformations are compiled. The observed contact-free arrangements of A-, B-, and Z-DNA are remarkably similar to the packing patterns found in DNA crystals. The formation of 'super' major and minor grooves is apparent in the complexes, especially those involving longer pieces. Such extended grooves may aid the wrapping and packaging of DNA chains in supramolecular assemblies.

Original languageEnglish (US)
Title of host publicationBiomedical Engineering Perspectives
Subtitle of host publicationHealth Care Technologies for the 1990's and Beyond
PublisherPubl by IEEE
Pages1613-1615
Number of pages3
Editionpt 4
ISBN (Print)0879425598
StatePublished - 1990
EventProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Philadelphia, PA, USA
Duration: Nov 1 1990Nov 4 1990

Publication series

NameProceedings of the Annual Conference on Engineering in Medicine and Biology
Numberpt 4
ISSN (Print)0589-1019

Other

OtherProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CityPhiladelphia, PA, USA
Period11/1/9011/4/90

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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