DNA Damage Response Pathway Alteration in Locally Advanced Clear-Cell Renal-Cell Carcinoma Is Associated With a Poor Outcome

Joon Chae Na, Naoya Nagaya, Koon Ho Rha, Woong Kyu Han, Isaac Yi Kim

    Research output: Contribution to journalArticlepeer-review

    12 Scopus citations

    Abstract

    We searched for a new therapeutic target for advanced clear-cell renal-cell carcinoma (ccRCC), the most common kidney cancer. The DNA damage response (DDR) pathway was investigated in 312 cases of localized ccRCC from The Cancer Genome Atlas database. Alterations in the DDR pathway are associated with increased recurrence in locally advanced ccRCC and may be a potential therapeutic target.

    Original languageEnglish (US)
    Pages (from-to)299-305.e1
    JournalClinical Genitourinary Cancer
    Volume17
    Issue number4
    DOIs
    StatePublished - Aug 2019

    All Science Journal Classification (ASJC) codes

    • Oncology
    • Urology

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