TY - JOUR
T1 - DNA immobilization and SAW response in ZnO nanotips grown on LiNbO 3 substrates
AU - Zhang, Zheng
AU - Emanetoglu, Nuri William
AU - Saraf, Gaurav
AU - Chen, Yimin
AU - Wu, Pan
AU - Zhong, Jian
AU - Lu, Yicheng
AU - Chen, Jingqiu
AU - Mirochnitchenko, Oleg
AU - Inouye, Masayori
PY - 2006/4
Y1 - 2006/4
N2 - DNA immobilization enhancement is demonstrated in a structure consisting of ZnO nanotips on 128° Y-cut LiNbO3. The ZnO nanotips are grown by metalorganic chemical vapor deposition (MOCVD) on the top of a SiO2 layer that is deposited and patterned on the LiNbO3 SAW delay path. The effects of ZnO nanotips on the SAW response are investigated. X-ray diffraction and scanning electron microscopy are used to analyze the ZnO nanotips, which are of single crystalline quality, and they are uniformly aligned with their c-axis perpendicular to the substrate surface. The photoluminescence (PL) spectrum of the ZnO nanotips shows strong near bandedge transition with insignificant deep level emission, confirming their good optical property. DNA immobilization enhancement is experimentally validated by radioactive labeling tests and SAW response changes. The ZnO nanotips enhance the DNA immobilization by a factor of 200 compared to ZnO film with flat surface. DNA hybridization with complementary and noncomplementary second strand DNA oligonucleotides is used to study the selective binding of the structure. This device structure possesses the advantages of both traditional SAW sensors and ZnO nanostructures.
AB - DNA immobilization enhancement is demonstrated in a structure consisting of ZnO nanotips on 128° Y-cut LiNbO3. The ZnO nanotips are grown by metalorganic chemical vapor deposition (MOCVD) on the top of a SiO2 layer that is deposited and patterned on the LiNbO3 SAW delay path. The effects of ZnO nanotips on the SAW response are investigated. X-ray diffraction and scanning electron microscopy are used to analyze the ZnO nanotips, which are of single crystalline quality, and they are uniformly aligned with their c-axis perpendicular to the substrate surface. The photoluminescence (PL) spectrum of the ZnO nanotips shows strong near bandedge transition with insignificant deep level emission, confirming their good optical property. DNA immobilization enhancement is experimentally validated by radioactive labeling tests and SAW response changes. The ZnO nanotips enhance the DNA immobilization by a factor of 200 compared to ZnO film with flat surface. DNA hybridization with complementary and noncomplementary second strand DNA oligonucleotides is used to study the selective binding of the structure. This device structure possesses the advantages of both traditional SAW sensors and ZnO nanostructures.
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U2 - 10.1109/tuffc.2006.1621506
DO - 10.1109/tuffc.2006.1621506
M3 - Article
C2 - 16615583
AN - SCOPUS:33645653729
SN - 0885-3010
VL - 53
SP - 786
EP - 791
JO - IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
JF - IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
IS - 4
ER -