DNA uptake during bacterial transformation

Inês Chen, David Dubnau

Research output: Contribution to journalReview article

420 Scopus citations


Naturally competent bacteria are able to take up exogenous DNA and undergo genetic transformation. The transport of DNA from the extracellular milieu into the cytoplasm is a complex process, and requires proteins that are related to those involved in the assembly of type IV pili and type II secretion systems, as well as a DNA translocase complex at the cytoplasmic membrane. Here, we will review the current knowledge of DNA transport during transformation.

Original languageEnglish (US)
Pages (from-to)241-249
Number of pages9
JournalNature Reviews Microbiology
Issue number3
StatePublished - Mar 1 2004

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology and Microbiology(all)
  • Infectious Diseases

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