Dorsal, an embryonic polarity gene in drosophila, is homologous to the vertebrate proto-oncogene, c-rel

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Abstract

The Drosophila. gene, dorsal, is a maternal effect locus that is essential for the establishment of dorsal-ventral polarity in the developing embryo. The dorsal protein was predicted from the complementary DNA sequence; it is almost 50 percent identical, over an extensive region, to the protein encoded by the avian oncogene v-rel, its cellular homolog, c-rel, and a human c-rel fragment. The oncogene v-rel is highly oncogenic in avian lymphoid, spleen, and bone marrow cells.

Original languageEnglish (US)
Pages (from-to)692-694
Number of pages3
JournalScience
Volume238
Issue number4827
DOIs
StatePublished - 1987
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

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