Double heterozygotes for non-Caucasian families with mutations in BRCA-1 and BRCA-2 genes

Doo Ho Choi, Min Hyuk Lee, Bruce Haffty

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The recent discovery of the BRCA-1 and BRCA-2 genes as contributing factors to hereditary breast cancer has significantly improved our understanding of familial breast cancer. Deleterious mutations in both BRCA-1 and BRCA-2 in an individual patient is exceedingly rare, with few case reports in the literature, particularly among non-Caucasian, non-Jewish families. We describe here two cases of deleterious mutations in both genes in a cohort of Korean women with early onset breast cancer.

Original languageEnglish (US)
Pages (from-to)216-220
Number of pages5
JournalBreast Journal
Volume12
Issue number3
DOIs
StatePublished - May 1 2006

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Surgery
  • Oncology

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