TY - JOUR
T1 - Dpbx, a new homeobox gene closely related to the human proto-oncogene pbxl molecular structure and developmental expression
AU - Flegel, Willy A.
AU - Singson, Andrew W.
AU - Margolis, Jonathan S.
AU - Bang, Anne G.
AU - Posakony, James W.
AU - Murre, Cornelis
N1 - Funding Information:
We thank James N. Kadonaga for providing the Drosophila cDNA library. W.A.F. was supported by research grant Fl173 from the Deutsche Forschungsge-meinschaft. This work was supported by NIH grants CA54198 and GM41100, the Searle the Council for Tobacco Research.
PY - 1993/5
Y1 - 1993/5
N2 - Recently, a new class of homeodomain containing proteins, pbx1, pbx2, and pbx3 has been described. pbx proteins are most closely related to two yeast regulatory proteins, a1 and α2. Here, we identify and characterize the pbx homolog in Drosophila, designated Dpbx. Dpbx is 95% identical to the pbx proteins within the homeodomain and, more remarkably, is 85% to 88% identical within a 201 amino acid region adjacent to the homeodomain. Cytologically, the Dpbx gene is located on the X chromosome at 14A. mRNA expression is both maternal and zygotic and occurs throughout the life cycle. Prior to full germband retraction, Dpbx is rather ubiquitously present and variations are minor. The most notable feature of Dpbx expression is that after germband retraction, high levels of Dpbx are observed in the anterior portion of the ventral nerve cord.
AB - Recently, a new class of homeodomain containing proteins, pbx1, pbx2, and pbx3 has been described. pbx proteins are most closely related to two yeast regulatory proteins, a1 and α2. Here, we identify and characterize the pbx homolog in Drosophila, designated Dpbx. Dpbx is 95% identical to the pbx proteins within the homeodomain and, more remarkably, is 85% to 88% identical within a 201 amino acid region adjacent to the homeodomain. Cytologically, the Dpbx gene is located on the X chromosome at 14A. mRNA expression is both maternal and zygotic and occurs throughout the life cycle. Prior to full germband retraction, Dpbx is rather ubiquitously present and variations are minor. The most notable feature of Dpbx expression is that after germband retraction, high levels of Dpbx are observed in the anterior portion of the ventral nerve cord.
KW - Central nervous system
KW - Dpbx
KW - Drosophila melanogaster development
KW - Homeobox gene
KW - Homeodomain
KW - Proto-oncogene
KW - pbx gene family
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U2 - 10.1016/0925-4773(93)90045-Y
DO - 10.1016/0925-4773(93)90045-Y
M3 - Article
C2 - 8100142
AN - SCOPUS:0027197205
SN - 0925-4773
VL - 41
SP - 155
EP - 161
JO - Mechanisms of Development
JF - Mechanisms of Development
IS - 2-3
ER -