Dpbx, a new homeobox gene closely related to the human proto-oncogene pbxl molecular structure and developmental expression

Willy A. Flegel, Andrew W. Singson, Jonathan S. Margolis, Anne G. Bang, James W. Posakony, Cornelis Murre

Research output: Contribution to journalArticle

43 Scopus citations


Recently, a new class of homeodomain containing proteins, pbx1, pbx2, and pbx3 has been described. pbx proteins are most closely related to two yeast regulatory proteins, a1 and α2. Here, we identify and characterize the pbx homolog in Drosophila, designated Dpbx. Dpbx is 95% identical to the pbx proteins within the homeodomain and, more remarkably, is 85% to 88% identical within a 201 amino acid region adjacent to the homeodomain. Cytologically, the Dpbx gene is located on the X chromosome at 14A. mRNA expression is both maternal and zygotic and occurs throughout the life cycle. Prior to full germband retraction, Dpbx is rather ubiquitously present and variations are minor. The most notable feature of Dpbx expression is that after germband retraction, high levels of Dpbx are observed in the anterior portion of the ventral nerve cord.

Original languageEnglish (US)
Pages (from-to)155-161
Number of pages7
JournalMechanisms of Development
Issue number2-3
StatePublished - May 1993
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Embryology
  • Developmental Biology


  • Central nervous system
  • Dpbx
  • Drosophila melanogaster development
  • Homeobox gene
  • Homeodomain
  • Proto-oncogene
  • pbx gene family

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