Drosophila DPP2C1, a novel member of the protein phosphatase 2C (PP2C) family

Thomas Dick, Sami M. Bahri, William Chia

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

We report the nuclear cloning, chromosome mapping and developmental pattern of a putative serine/threonine protein phosphates 2C(PP2C), DPP2C1, from Drosophila melanogaster. The 6-kb transcript of this first Drosophila PP2C gene encodes a 1,428-aa deduced protein. The DPP2C1 protein contains a ≃ 330-aa PP2C-like catalytic domain flanked by extensive N- and C-terminal sequences showing no similarities to other PP2Cs. The dpp2c1 gene maps to 4E1-2 on the X chromosome, 1.5kb upstream of the ddlc1 gene. Northern blot analyses showed that dpp2c1 transcription is developmentally regulated, accumulating maximally during early (0-6h) and late (12-24h) embryogenesis. The presented molecular characterisation provides the basis for a genetic dissection of DPP2C1 function.

Original languageEnglish (US)
Pages (from-to)139-143
Number of pages5
JournalGene
Volume199
Issue number1-2
DOIs
StatePublished - Oct 15 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics

Keywords

  • 4E1-2
  • PPM
  • X chromosome

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