Background: Drosophila trpml mutants reproduced many defects associated with mucolipidosis type IV, but the flyTRPML channel remains uncharacterized. Results: Drosophila TRPML is a phosphoinositide-regulated cation channel on endolysosome and plasma membranes. Conclusion: Fly TRPML largely resembles mammalian TRPML1, but exhibits differences in subcellular localization and pH dependence. Significance: The data support using Drosophila for assessing TRPML1 function.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology