Drug Metabolism in Pregnancy

J. E. Moscovitz, L. Gorczyca, L. M. Aleksunes

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter provides an overview of the physiologic and pharmacokinetic changes that influence drug disposition during pregnancy. The dynamic regulation of hepatic phases I and II metabolic enzymes as well as transporters in pregnant animals and women is reviewed. Attention is also placed upon the role of individual hormones, such as estradiol and progesterone, as well as nuclear receptors in the adaptive changes in enzyme and transporter levels that occur during pregnancy. A comprehensive case study explores the coordinated regulation of metabolic enzymes, transporters, and nuclear receptors that control bile acid homeostasis in pregnant rodents. Understanding how pregnancy alters endobiotic and xenobiotic disposition is critical to ensure optimal management of diseases.

Original languageEnglish (US)
Title of host publicationDrug Metabolism in Diseases
PublisherElsevier Inc.
Pages207-240
Number of pages34
ISBN (Electronic)9780128029633
ISBN (Print)9780128029497
DOIs
StatePublished - Jan 1 2017

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

Keywords

  • Fetus
  • Metabolism
  • Physiology
  • Pregnancy
  • Transport

Cite this

Moscovitz, J. E., Gorczyca, L., & Aleksunes, L. M. (2017). Drug Metabolism in Pregnancy. In Drug Metabolism in Diseases (pp. 207-240). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-802949-7.00009-2