Drug Metabolism in Pregnancy

J. E. Moscovitz, L. Gorczyca, L. M. Aleksunes

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


This chapter provides an overview of the physiologic and pharmacokinetic changes that influence drug disposition during pregnancy. The dynamic regulation of hepatic phases I and II metabolic enzymes as well as transporters in pregnant animals and women is reviewed. Attention is also placed upon the role of individual hormones, such as estradiol and progesterone, as well as nuclear receptors in the adaptive changes in enzyme and transporter levels that occur during pregnancy. A comprehensive case study explores the coordinated regulation of metabolic enzymes, transporters, and nuclear receptors that control bile acid homeostasis in pregnant rodents. Understanding how pregnancy alters endobiotic and xenobiotic disposition is critical to ensure optimal management of diseases.

Original languageEnglish (US)
Title of host publicationDrug Metabolism in Diseases
PublisherElsevier Inc.
Number of pages34
ISBN (Electronic)9780128029633
ISBN (Print)9780128029497
StatePublished - Jan 1 2017

All Science Journal Classification (ASJC) codes

  • General Medicine


  • Fetus
  • Metabolism
  • Physiology
  • Pregnancy
  • Transport


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