Drug-nucleic acid interactions: Conformational flexibility at the intercalation site

H. M. Berman, S. Neidle, R. K. Stodola

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

The conformational features of the intercalation site in polynucleotides were examined. We found that, for all the crystal structures of drug-dinucleoside complexes studied thus far, two torsion angles differ from those found in A RNA (θ and χ) and that alternate sugar puckering is not a prerequisite for intercalation. This intercalation geometry, which is the basis of helix axis displacement in a polymer, would necessitate conformational changes in the adjacent nucleotides. The base-turn angle is less sensitive to the conformation of the backbone than it is to small alterations in the base-pairing geometry. We postulate that this angle is dependent on the nature of the intercalating drug.

Original languageEnglish (US)
Pages (from-to)828-832
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume75
Issue number2
DOIs
StatePublished - 1978
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

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