Dying-back oligodendrogliopathy: A late sequel of myelin-associated glycoprotein deficiency

Hans Lassmann, Udo Bartsch, Dirk Montag, Melitta Schachner

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

Ultrastructural analysis of myelin from 8-month-old mice deficient in the myelin-associated glycoprotein revealed pronounced and characteristic alterations of the periaxonal oligodendrocyte processes, consisting of intracytoplasmic deposition of vesicular material, multivesicular bodies, mitochondria, and lipofuscin granules, as well as granular or paracrystalline inclusions. These alterations are similar to those described before as 'dying-back oligodendrogliopathy' in diseases of toxic or immune-mediated demyelination including multiple sclerosis.

Original languageEnglish (US)
Pages (from-to)104-110
Number of pages7
JournalGlia
Volume19
Issue number2
DOIs
StatePublished - Feb 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neurology
  • Cellular and Molecular Neuroscience

Keywords

  • gene ablation
  • mouse
  • oligodendrocyte pathology

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